Month: March 2021

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3391-86-4, name is Oct-1-en-3-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Oct-1-en-3-ol

General procedure: In a Schlenk tube, 11.5 mg (4 105 mol) Na2CO310H2O wasdissolved in 4.6 mL H2O. After deoxygenation, 9.3 mg (2 105mol) [RuCl2(pta)(g6-p-cymene)] was added and the solution wasstirred for 15 min at 80 C. 310 lL (2.02 mmol) oct-1-en-3-ol wasinjected to the catalyst solution and the reaction mixture was stirredfurther at 80 C. At the end of the desired reaction time themixture was cooled and extracted with hexane under air. Theorganic phase was dried on MgSO4 and analyzed by gas chromatography.Products were identified by comparison of theirretention times to standards and the composition of the productmixture was calculated from peak areas.In recycling experiments, following extraction and phase separation,the aqueous phase was deoxygenated, heated to 80 C, anew batch of the substrate was added and the reaction was initiatedby stirring.

With the rapid development of chemical substances, we look forward to future research findings about 3391-86-4.

Reference:
Article; Bolyog-Nagy, Evelin; Udvardy, Antal; Barczane-Bertok, Agnes; Joo, Ferenc; Katho, Agnes; Inorganica Chimica Acta; vol. 455; (2017); p. 514 – 520;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 764-48-7, name is Ethylene Glycol Vinyl Ether. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

1) Production of 2-[(6-bromopyridin-2-yl)oxy]ethanol 8.81 g of ethylene glycol monovinyl ether was added to toluene (100 mL) suspension of 2.4 g of sodium hydride (55% to 72%), and 9.48 g of 2,6-dibromopyridine was added thereto and stirred overnight at 110 C. The reaction liquid was left cooled to room temperature, and water was added thereto to separate the organic layer. This was washed with saturated saline water, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure. 100 mL of methanol and 576 mg of p-toluenesulfonic acid hydrate were added to the resulting residue, and stirred for 5 hours. After this was concentrated under reduced pressure, aqueous saturated sodium hydrogencarbonate solution was added to it, and extracted with ethyl acetate. This was washed with saturated saline water, dried with anhydrous magnesium sulfate, concentrated under reduced pressure, and the resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=9/1 to 2/1) to obtain 7.74 g of the entitled compound as a colorless oily substance. 1H-NMR (400 MHz, CDCl3) delta: 7.45 (1H, t, J=7.5 Hz), 7.09 (1H, d, J=7.4 Hz), 6.74 (1H, d, J=8.2 Hz), 4.46 (2H, t, J=4.4 Hz), 3.96 (2H, t, J=4.4 Hz). ESI-MS Found: m/z[M+H]+ 218, 220.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 764-48-7, Ethylene Glycol Vinyl Ether.

Reference:
Patent; Sagara, Takeshi; Otsuki, Sachie; Sunami, Satoshi; Sakamoto, Toshihiro; Niiyama, Kenji; Yamamoto, Fuyuki; Yoshizumi, Takashi; Furuyama, Hidetomo; Goto, Yasuhiro; Bamba, Makoto; Takahashi, Keiji; Hirai, Hiroshi; Nishibata, Toshihide; US2007/254892; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.597-31-9, name is 3-Hydroxy-2,2-dimethylpropanal, molecular formula is C5H10O2, molecular weight is 102.1317, as common compound, the synthetic route is as follows.Computed Properties of C5H10O2

EXAMPLE 2 (COMPARATIVE EXPERIMENT)Hydrogenation of the HPA-Comprising Stream from Example 1The HPA-comprising stream used was the mixture prepared according to example 1.This HPA-comprising stream was first passed into a hydrogenation reactor which was operated in trickle mode at H2 pressure 37-40 bar and at 100-120 C. The hourly space velocity was 0.28 kg of solution/(1 cat.*h). The catalyst used was a Cu/Al2O3 catalyst as described in EP-A-44444 or WO-A-2007/042456, which was activated according to the disclosure of EP-A-44444 or WO-A-2007/042456 in a tubular reactor at 190 C. at ambient pressure by passing a mixture of 5% by volume of hydrogen and 95% by volume of nitrogen (total volume 50 1 (STP)/h) over it for 24 h.The hydrogenation discharge was split into two substreams.In steady-state operation, one substream as the NPG-comprising circulation stream was combined with the HPA-comprising stream.The ratio of NPG-comprising circulation stream to the HPA-comprising stream from example 1 was approx. 10:1.The composition of the circulation stream was 25% by weight of water, 68% by weight of NPG, 1.6% by weight of HPA, remainder (approx. 6% by weight) other organic compounds.The hydrogenation feed thus obtained was subsequently introduced into the hydrogenation reactor.The composition of the hydrogenation feed was 25% by weight of water, 64% by weight of NPG, 7% by weight of HPA and 4% by weight of other organic compounds.The weight ratio of HPA to NPG in the hydrogenation feed was approx. 1:9.The portion of the hydrogenation discharge which was not recycled as the NPG-comprising circulation stream was conducted through a second hydrogenation reactor.The second hydrogenation reactor was operated at 37-40 bar and a temperature of 110-130 C. The catalyst used was the same catalyst as in the first hydrogenation reactor.A pH of approx. 8 was established in the discharge of the second reactor, by adding trimethylamine (TMA) (pH regulator) to the HPA-comprising stream from example 1.The pH regulator was supplied before the combination of the HPA-comprising stream with the NPG-comprising circulation stream.The temperature of the HPA-comprising stream from example 1 on supply of the pH regulator (TMA) was 80 C. The residence time between the addition of the pH regulator and the supply of the circulation stream was 10 minutes (>5 minutes).EXAMPLE 3 (INVENTIVE EXAMPLE)Hydrogenation of the HPA-Comprising Stream from Example 1The hydrogenation was effected under the same conditions as in example 2. To establish a pH of 8 at the outlet of the second reactor, the pH regulator (TMA) was, however, supplied directly to the NPG-comprising circulation stream before the NPG-comprising stream was combined with the HPA-comprising stream from example 1. The weight ratio of HPA to NPG in the hydrogenation feed obtained by combining these streams was approx. 1:9.The composition of the hydrogenation feed was 25% by weight of water, 64% by weight of NPG, 7% by weight of HPA and 4% by weight of other organic compounds.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,597-31-9, 3-Hydroxy-2,2-dimethylpropanal, and friends who are interested can also refer to it.

Reference:
Patent; BASF SE; US2011/282106; (2011); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37585-16-3, name is (2-Amino-4-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H8ClNO

General procedure: To a solution of 1a (1.2 g, 7.61 mmol) in CH2Cl2 (20 mL) was added MnO2 (2.6 g, 30.1 mmol) and stirred at rt under an Ar atmosphere. After 23 h with stirring, the reaction mixture was filtrated and evaporated. The residue was crystallized from AcOEt to give 7a (1.0 g, 85%) as a yellow needle crystal.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 37585-16-3, (2-Amino-4-chlorophenyl)methanol.

Reference:
Article; Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi; Bioorganic and Medicinal Chemistry; vol. 20; 19; (2012); p. 5810 – 5831;,
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Adding a certain compound to certain chemical reactions, such as: 623-50-7, Ethyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C4H8O3, blongs to alcohols-buliding-blocks compound. COA of Formula: C4H8O3

A suspension of sodium hydride (11.2 g, 60% dispersion in mineral oil, 280 mmol) in1 ,2-dimethoxyethane (250 mL) was cooled to 000, treated dropwise with ethyl glycolate(25.5 mL, 269 mmol) and stirred at 23 00 for 30 mi Ethyl-2-chloronicotinate (20.0 g, 108 mmol) in 1,2-dimethoxyethane (40 mL) was added dropwise over 10 mm and the mixture was stirred at 70 00 for 15 hours. The solvent was evaporated, the residue dissolved in water (500 mL) and washed with toluene. The aqueous layer was acidifiedwith acetic acid (19 mL) to pH Sand extracted five times with CH2CI2 (5 x 100 mL). The combined organic layers were dried over anhydrous MgSO4, filtered and the solvent evaporated. Column chromatography (Si02 EtOAc/Heptane, 20:80 ->50:50) of the crude gave ethyl 3-hydroxyfuro[2,3-b]pyridine-2-carboxylate (21.1 g, 94%) as a yellow solid.1H NMR (400 MHz, Chloroform-o) 6 = 8.52 (dd, J= 4.9, 1.7 Hz, 1H, H-Ar), 8.12 (dd, J7.8, 1.7 Hz, 1H, H-Ar), 7.31 (dd, J= 7.8, 4.8 Hz, 1H, H-Ar), 4.47 (q, J= 7.1 Hz, 2H, 0-CH2CH3), 4.13 (s, 1H, OH), 1.44 (t, J= 7.1 Hz, 3H, 0-CH2CH3) ppm.MS (ESI+, H20/MeCN) mlz(%): 208.0 (100, [M + H]j.

The synthetic route of 623-50-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EUROPEAN MOLECULAR BIOLOGY LABORATORY; WILL, David William; REID, George; CHARAPITSA, Iryna; LEWIS, Joe David; (187 pag.)WO2018/229193; (2018); A1;,
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Reference of 172023-97-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 172023-97-1, name is (3-Bromo-5-(trifluoromethyl)phenyl)methanol, molecular formula is C8H6BrF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1-Bromo-3-(bromomethyl)-5-(trifluoromethyl)benzene. (3-Bromo-5-(trifluoromethyl)phenyl)methanol (1.6 g, 6.3 mmol) and triphenylphosphine (3.3 g, 12.6 mmol) were combined in tetrahydrofuran (30 mL) and cooled to 0 C. N-Bromosuccinimide (2.4 g, 13.2 mmol) was introduced in portions and the reaction allowed to warm to room temperature. After 16 h, the reaction mixture was diluted with ethyl acetate, washed with concentrated sodium bicarbonate (2¡Á), brine (2¡Á), dried over sodium sulfate, and concentrated. Column chromatography on silica gel (100% hexanes) gave 1.53 g (76%) as a light brown oil. 1H-NMR (CDCl3, 500 MHz) delta 7.73 (s, 1H), 7.70 (s, 1H), 7.58 (s, 1H), 4.44 (s, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 172023-97-1, (3-Bromo-5-(trifluoromethyl)phenyl)methanol.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/249607; (2007); A1;,
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Electric Literature of 39590-81-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane, molecular formula is C5H10O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(1) [1-(tert-Butyldiphenylsilanyloxymethyl)cyclopropyl]methanol 1,1-Bis(hydroxymethyl)cyclopropane (2 g) and imidazole (6.67 g) were dissolved in N,N-dimethylformamide (100 mL) and the solution was ice-cooled. tert-Butyldiphenylchlorosilane (5.39 g) was added dropwise to the solution. Then, the reaction mixture was gradually heated to room temperature and stirred for 18 hours. tert-Butyl methyl ether and a saturated sodium chloride solution were added to the reaction mixture, and the organic layer was separated. The organic layer was dried over anhydrous magnesium sulfate. The drying agent was removed by filtration. The filtrate was concentrated under reduced pressure to obtain a residue. The residue was subjected to silica gel column chromatography (heptane-ethyl acetate) to obtain the title compound (2.62 g). 1H-NMR (400 MHz, CDCl3) delta (ppm): 0.30-0.40 (m, 2H), 0.45-0.53 (m, 2H), 1.07 (s, 9H), 2.56 (t, J=5.6 Hz, 1H), 3.61 (d, J=5.6 Hz, 2H), 3.62 (s, 2H), 7.35-7.46 (m, 6H), 7.64-7.70 (m, 4H).; (1) [1-(tert-Butyldiphenylsilanyloxymethyl)cyclopropyl]methanol 1,1-Bis(hydroxymethyl)cyclopropane (3.6 g) and imidazole (2.4 g) were dissolved in N,N-dimethylformamide (35 mL) in a nitrogen atmosphere. tert-Butylchlorodiphenylsilane (9.2 mL) was added to the solution at -15C, and the mixture was stirred at – 15C for one hour. Methanol and water were sequentially added to the reaction mixture, followed by extraction with ethyl acetate twice. The organic layers were sequentially washed with water and a saturated sodium chloride solution and dried over magnesium sulfate. The drying agent was removed by filtration and then the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (heptane-ethyl acetate) to obtain the title compound (5.58 g). 1H-NMR (400 MHz, CDCl3) delta(ppm): 0.34-0.38 (m, 2H), 0.47-0.51 (m, 2H), 1.06 (s, 9H), 2.57 (t, J=5.6 Hz, 1H), 3.61 (d, J=5.6 Hz, 2H), 3.62 (s, 2H), 7.35-7.45 (m, 6H), 7.64-7.68 (m, 4H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 39590-81-3, 1,1-Bis(Hydroxymethyl)cyclopropane.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2017275; (2009); A1;,
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Related Products of 6282-88-8 ,Some common heterocyclic compound, 6282-88-8, molecular formula is C9H11ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(f) 135 ml of pyridine are added dropwise to 150 g of 3-(4-chlorophenyl)-propan-1-ol and 206.6 g of p-toluenesulphonyl chloride in 300 ml of chloroform at 0. After the addition, the mixture is stirred at room temperature for 3 hours and the solution is poured into a mixture of 400 ml of water and 120 ml of concentrated hydrochloric acid. The organic phase is separated off, washed 3 times with water, dried over sodium sulphate and concentrated to a yellowish viscous oil in vacuo, yield: 285 g of p-toluenesulphonic acid 3-(4-chlorophenyl)-propyl ester.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6282-88-8, 3-(4-Chlorophenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Byk Gulden Lomberg Chemische Fabrik Gesellschaft; US4334089; (1982); A;,
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Adding a certain compound to certain chemical reactions, such as: 534-03-2, 2-Aminopropane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

The preparation of (S)-1-((3,5-bis((1,3-dihydroxypropan-2-yl)carbamoyl)-2,4,6-triiodo-phenyl)amino)-1-oxopropan-2-yl acetate was carried taking as reference the procedures described in the literature. 20 g (28.2 mmol) of (S)-1-((3,5-bis(chlorocarbonyl)-2,4,6-triiodophenyl)amino)-1-oxopropan-2-yl acetate from example 3 was reacted with 2-amino-1,3-propanediol (6.4 g, 70.5 mmol) in DMA (100 ml) in the presence of triethylamine (10.0 ml, 71.4 mmol) at 50 C. for 6 hours. After complete reaction and removal of the salts by filtration, the solvent was distilled under vacuum at below 70 C. until a viscous oil was obtained. While the residue was still hot, alcohol was added (20 ml) to fluidize, followed by the addition of acetone (120 ml) in portions for about 1 hour and reflux for another hour. The resulting suspension was filtered and the product was dried under vacuum at 50 C. for 16 hours to give (S)-1-((3,5-bis((1,3-dihydroxypropan-2-yl)carbamoyl)-2,4,6-triiodophenyl)amino)-1-oxopropan-2-yl acetate as a white solid (19.0 g, 23.1 mmol). [0026] Yield: 82.0% [0027] HPLC purity: 98% (including 2% lopamidol)

The synthetic route of 534-03-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HOVIONE INTER LIMITED; Galindro, Jose Manuel; Cruz, Ana Cristina; Bandarra, Joao Jose; Heggie, William; US2014/155648; (2014); A1;,
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Related Products of 349-75-7, Adding some certain compound to certain chemical reactions, such as: 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol,molecular formula is C8H7F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 349-75-7.

Example 11; [Show Image] Compound 6 was reacted with various benzylalcohols to give Compounds A-21, A-22, A-23 and A-24 via Mitsunobu reaction.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 349-75-7, (3-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shionogi & Co., Ltd.; EP1953145; (2008); A1;,
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