Month: March 2021

Synthetic Route of 616-29-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1 ,3-diaminopropan-2-ol (200mg, 2.22mmols) was dissolved in 20ml methanol and triethylamine (20ml) was added dropwise. Boc anhydride (3eq) was then added and heated at 50C for 20min and 1 hr at room temperature. This was monitored by TLC (9:1) DCM:methanol. After completion saturated solution of NaHCC was added (40ml) and extracted with ethyl acetate. The solvent was evaporated in vacuo and used in the next step without purification.

According to the analysis of related databases, 616-29-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UNIVERSITY OF LINCOLN; SINGH, Ishwar; TAYLOR, Edward; (137 pag.)WO2018/162922; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1777-82-8, (2,4-Dichlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H6Cl2O, blongs to alcohols-buliding-blocks compound. Formula: C7H6Cl2O

General procedure: In a 50ml Pyrex round-bottom flask, a mixture of alcohol (1mmol), TBATB (10-20mg, 0.02-0.04mmol) in 10ml of CH3CN was exposed to blue or violet light LED irradiation at room temperature under an air atmosphere with stirring. The progress of the photocatalytic oxidation reaction was monitored by TLC on silica gel plates. The reaction mixture externally irradiated until the alcohol was completely consumed.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1777-82-8, (2,4-Dichlorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Mardani, Atefeh; Heshami, Marouf; Shariati, Yadollah; Kazemi, Foad; Abdollahi Kakroudi, Mazaher; Kaboudin, Babak; Journal of Photochemistry and Photobiology A: Chemistry; vol. 389; (2020);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 589-98-0, name is 3-Octanol. This compound has unique chemical properties. The synthetic route is as follows. name: 3-Octanol

1.31 g (10.1 mmol) of 3-octanol,0.170 g (0.50 mmol) of tetrabutylammonium hydrogensulfate and 0.0155 g (0.10 mmol) of TEMPO were dissolved in 30 mL of dichloromethane and charged into the reaction vessel. After the liquid temperature in the reaction vessel was cooled to 5 DEG C, 1.98 g (12.0 mmol) of the crystals of sodium hypochlorite pentahydrate was added with stirring, and then the liquid temperatureThe mixture was kept at 5 DEG C and stirredOxidation reaction was carried out. After 1 hour from the start of the oxidation reaction, internal standard analysis was carried out by GC in the same manner as in Example 1 to find that 3-octanone was produced at a yield of 97%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 589-98-0, 3-Octanol.

Reference:
Patent; NIPPON LIGHT METAL COMPANY, LIMITED; TOMOHIDE, OKADA; TOMOTAKE, ASAWA; YUKIHIRO, SUGIYAMA; (9 pag.)KR2015/26729; (2015); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2050-25-1, Adding some certain compound to certain chemical reactions, such as: 2050-25-1, name is 2-(2-(Benzyloxy)ethoxy)ethanol,molecular formula is C11H16O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2050-25-1.

tert-Butyl 2 – (2 – (2 – (benzyloxy) ethoxy) ethoxy) acetate KOtBu (20 mL, 20 mmol) was added to a stirred solution of 2-(2-(benzyloxy)ethoxy)ethanol (commercially available from for example Aldrich) (2.74 mL, 15 mmol) in tBuOH (30 mL) and the mixture was stirred under a nitrogen atmosphere at room temperature for 2 hours. The reaction mixture was cooled to 0C, tert-butyl 2-bromoacetate (commercially available from for example Aldrich) (4 mL, 28 mmol) was added and the mixture stirred at room temperature overnight. The reaction mixture was then concentrated, and partitioned between water (50 mL) and DCM (50 mL). The organic layer was separated and the aqueous layer was extracted further with DCM (50 mL). The combined organic layers were dried using a hydrophobic frit and concentrated under reduced pressure. The product was purified by chromatography on silica using a gradient elution from 0 % to 100 % methyl tert-butyl ether in cyclohexane to afford the title compound (3.56 g, 11 mmol, 74% yield). LCMS RT= 1.11 min, ES+ve m/z 311.4 [M+H]+, 328.4 [M+NH4] +.

According to the analysis of related databases, 2050-25-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CAMPOS, Sebastien, Andre; HARLING, John, David; MIAH, Afjal, Hussain; SMITH, Ian, Edward, David; WO2015/867; (2015); A1;,
Alcohol – Wikipedia,
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Application of 57641-67-5 ,Some common heterocyclic compound, 57641-67-5, molecular formula is C6H13BrO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-[2-(2-bromoethoxy)ethoxy]ethanol (0.12 g, 0.547 mmol, 2 mL) was added to a solution of rapamycin (0.5 g, 0.547 mmol) and p-toluenesulfonic acid hydrate (0.5 g, 2.73 mmol) in THF (7 mL) at room temperature and the resulting mixture was stirred for 2 hours. Ice cold NaHCO3 aqueous solution was then added and the mixture was extracted with EtOAc (30 mL ¡Á 3). The organic phase was then dried over Na2SO4, filtered, and concentrated in vacuo. The resulting crude material was purified by reverse phase chromatography (CH3CN/pure water = 7:3) to obtain (21E,23E,25E,26E,34R,35S,36R,37R, 39R,41S,44S,45R,46R,55S)-43-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-45,55-dihydroxy-44- [(1S)-2-[(1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl]-1-methyl-ethyl]-46-methoxy-34,35, 36,37,47,48-hexamethyl-65,66-dioxa-56-azatricyclohexatriaconta-21,23,25(47),26(48)- tetraene-49,50,51,52,53-pentone (0.2 g, 33.4% yield, 1HNMR shows a rapamycin impurity) as a white solid. MS (EI+, m/z): 1116.4 [M+Na] +.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,57641-67-5, its application will become more common.

Reference:
Patent; NAVITOR PHARMACEUTICALS, INC.; SAIAH, Eddine; O’NEILL, David, John; KANG, Seong Woo Anthony; (366 pag.)WO2019/241789; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 33420-52-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33420-52-9, name is 2,2-Difluoropropan-1-ol, molecular formula is C3H6F2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of Intermediate Trifluoromethanesulfonic acid 2,2-difluoropropyl ester (I-4A-4c): To a solution of 2,2-difluoro-propan-1-ol (I-4A-4b, 1.76 g, 18.3 mmol), DMAP (157 mg, 1.3 mmol), and NEt3 (2.20 g, 3.1 ml, 22 mmol) in CH2Cl2 (15 ml) at 0 C. was added trifluoromethanesulfonic anhydride (Tf2O, 6.20 g, 3.7 ml, 22 mmol). The reaction mixture initially turned a pink color, then a yellow color following the complete addition of Tf2O. The reaction mixture was stirred at 0 C. for 2 h and diluted with CH2Cl2. The organic solution was washed with H2O, 1 M citric acid, and saturated aqueous NaHCO3, dried, and concentrated under reduced pressure (225 mm/Hg; water bath temperature -30 C.) to give the desired product, trifluoromethanesulfonic acid 2,2-difluoro-propyl ester (I-4A-4c), as a pink oil (3 g, 72%): 1H NMR (400 MHz, CDCl3): delta 4.49 (t, 2H, J=10.8 Hz), 1.74 (t, 3H).

According to the analysis of related databases, 33420-52-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pfizer Inc; US2004/214838; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol, molecular formula is C7H6Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 1805-32-9

General procedure: A mixture of the substrate (1 mmol), hexamethyldisilazane (0.70 mmol), and/or 3,4-dihydro-2H-pyran (1.4 mmol) and BiPy(SO3H)2(HSO4)2 (10 mg, 1.95 mol%) in CH3CN(3 mL) and/or CH2Cl2 (3 mL) was stirred at room temperature. The progress of thereaction was monitored by TLC (n-hexane: EtOAc; 10:1) and/or GC. After completion ofthe reaction, the mixture was filtered to separate the solid catalyst. Then the solution wasfiltered through a silica gel pad and washed with CH3CN (2 ¡Á 3 mL) and/or CH2Cl2 (2 ¡Á3 mL). Evaporation of the solvent gave the desired products in high purity.

With the rapid development of chemical substances, we look forward to future research findings about 1805-32-9.

Reference:
Article; Shirini, Farhad; Abedini, Masoumeh; Mahmoodi, Nosratollah; Biglari, Mohammad; Safarpoor Nikoo Langrudi, Mohaddeseh; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 190; 11; (2015); p. 1912 – 1921;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 722-92-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 722-92-9 as follows.

A solution of [2- (4-AMINOPHENYL)-1,] 1,1, 3,3, 3-hexafluoropropan-2-ol (Oakwoood, [1] g, 3.9 [MMOL)] and 2, [4-DICHLOROBENZALDEHYDE] in methanol (21 mL) was stirred at ambient temperature. After 18 hours, glacial acetic acid (0.24 mL, 4.25 [MMOL)] and sodium [CYANOBOROHYDRIDE] (388 mg, 4.25 [MMOL)] were added. After stirring an additional 18 hours, the mixture was [CONCENTRATED IN VACUO] and the residue dissolved in EtOAc. The organic layer was washed several times with brine, dried [(NA2SO4),] filtered, and concentrated. Purification by flash chromatography (4: 1 hexanes/EtOAc) afforded the title compound as a white waxy solid (1.6 g, 99percent). MS (ES+) [M/Z] 418 (M+), 420 (M+2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,722-92-9, its application will become more common.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 7589-27-7, Adding some certain compound to certain chemical reactions, such as: 7589-27-7, name is 2-(4-Fluorophenyl)ethanol,molecular formula is C8H9FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7589-27-7.

A mixture of 2,5-dichloronicotinic acid (0.30 g, 1.6 mmol), 2-(4- fluorophenyl)ethanol (0.23 mL, 1.9 mmol), and sodium hydride in oil (0.15 g, 3.7 mmol) in N, N-dimethylforamide (2 mL) was heated at 90 ¡ãC in an oil bath for 3 hours. The reaction mixture was poured into 10percent citric acid aqueous solution (50 mL), and extracted with ethyl acetate (50 mL x 2). The combined organic layers were washed with water (50 mL x 2) and brine (50 mL), dried (magnesium sulfate), and evaporated. The crude solids were washed with hexane/ether (10/1), and dried in vacuo to afford 0.31 g (68percent) of the title compound as white solids: (at)H-NMR (CDCI3) 8 8.41 (1 H, d, J = 2.8 Hz), 8.31 (1 H, d, J = 2.8 Hz), 7.27-7.20 (2H, m), 7.08-6.98 (2H, m), 4.78 (2H, t, J = 6.8 Hz), 3.15 (2H, t, J = 6.8 Hz) ; MS (ESI) m/z 294 (M – H)-

According to the analysis of related databases, 7589-27-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2005/102389; (2005); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 25574-11-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25574-11-2, name is 3-(4-Bromophenyl)propan-1-ol, molecular formula is C9H11BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 3-(4-bromophenyl)propanol (8.15 g, 37.9 mmol), potassium acetate (11.2 g, 113.7 mmol), bis(pinacolato)diboron (10.6 g, 41.7 mmol), dimethyl sulfoxide (150 mL) and 1, l ‘-bis(diphenyl-phosphino) ferroncene-palladium dichloride dichloromethane complex (1:1) (1.55 g, 1.89 mmol) was heated at 800C under nitrogen overnight. Upon cooling, the reaction mixture was poured into water (-300 mL), and the product was extracted with Et2O-hexanes (1:1) (3x300mL). The combined organic extracts were washed with water (~300 mL), brine, dried (Na2SO4) and concentrated to afford 3-[4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)phenyl]propanol, which was used without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 25574-11-2, 3-(4-Bromophenyl)propan-1-ol.

Reference:
Patent; MERCK & CO., INC.; WO2008/51405; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts