Month: March 2021

Adding a certain compound to certain chemical reactions, such as: 647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol

General procedure: A two-necked, 500-mL round bottom flask was equipped with a magnetic stirring bar and a three-way stopcock, of which one way was connected to an argon flow line and the other was connected to a vacuum line. The apparatus was flame-dried in vacuum, and allowed to cool to room temperature under an argon purge. To a solution of [IrCl(cod)]2 (1 mol%) in dry toluene triethylene glycol monomethyl ether, vinyl acetate (2.0 equiv), and Na2CO3 (0.60 equiv) were added and the mixture was stirred at 100 C for 3 h. After the reaction, the resulting salts were removed and washed with Et2O. The solvent was removed under reduced pressure. Purification of the residue by vacuum distillation (2 times distillation with CaH2) gave the product.

The synthetic route of 647-42-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Harada, Nari-Aki; Nishikata, Takashi; Nagashima, Hideo; Tetrahedron; vol. 68; 15; (2012); p. 3243 – 3252;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2043-47-2, Adding some certain compound to certain chemical reactions, such as: 2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol,molecular formula is C6H5F9O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2043-47-2.

Example 14 Production of Exemplified Compound 126 {circle around (1)}: A solvent comprising 1.1 g of triethylamine and 5 g of toluene was added dropwise to a mixture comprising 2.47 g of 4-benzyloxybenzoic chloride (this compound was prepared from 4-benzyloxybenzoic acid and oxalyl chloride), 2.64 g of 2-n-perfluorobutylethanol and 10 g of toluene in 30 minutes. After finishing the adding dropwise, the mixture was stirred at room temperature for 6 hours. Deposited salts were filtered off, and the filtrate was neutralized with 1/2 N hydrochloric acid and washed with water. Then, toluene was distilled off under reduced pressure, and the resultant residue was recrystallized from methanol, whereby 3.3 g of 4-benzyloxybenzoic acid 2′-n-perfluorobutylethyl ester was obtained in the form of a colorless crystal.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2043-47-2, 1H,1H,2H,2H-Nonafluoro-1-hexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Mitsui Chemicals, Inc.; US6217793; (2001); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H6Cl2O

General procedure: The solution of the crude 6D’ and Ph3PHBr (2.16 g, 6.3mmol) in CH3CN was refluxed overnight. Evaporation ofthe reaction mixture yielded 2.25 g of crude compound 7D’ as a white solid in 76% yield (2 steps) and used for the next reaction without further purification

With the rapid development of chemical substances, we look forward to future research findings about 1805-32-9.

Reference:
Article; Kim, Sung-Soo; Fang, Yuanying; Park, Haeil; Bulletin of the Korean Chemical Society; vol. 36; 6; (2015); p. 1676 – 1680;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 4249-72-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4249-72-3, name is 2-Phenoxy-1-phenylethanol, molecular formula is C14H14O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Lignin model molecule (2-phenoxy-1-phenylethanol) wassynthesized according to the method reported by Rothenberg[9]. Catalytic hydrotreating of 2-phenoxy-1-phenylethanolwas carried out in a 100ml autoclave with Tefon liner.The catalyst (50mg) was added to a solution of 2-phenoxy-1-phenylethanol (150mg) in ethanol (2ml) and H2O(8ml).The autoclave was sealed and purged with H2several times.The reaction was performed at 170C with 2MPa hydrogenpressure for 6h. Then, the reactors were cooled down toroom temperature using an ice bath, and the organic productswere extracted with ethyl acetate (5ml ¡Á 2). The organic products mixtures were analyzed by GC and chlorobenzenewas used as an external standard. Identification of mainproducts was based on GC-MS as well as by comparisonwith authentic samples. The product distribution was shownon the mole basis. In consecutive batch tests, the catalystwas recovered by magnets and washed with EtOH for threetimes. The catalyst was recycled into the autoclave with thefeedstream.

According to the analysis of related databases, 4249-72-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chen, Bingfeng; Li, Fengbo; Yuan, Guoqing; Catalysis Letters; vol. 147; 11; (2017); p. 2877 – 2885;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1562-00-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1562-00-1, name is Sodium isethionate. This compound has unique chemical properties. The synthetic route is as follows.

0.675 mol of isethionic acid sodium salt (100.0 g) and 2.02 mol benzylchloride (233 mL) were mixed in a 750 mL multi-necked flask with KPG-stirrer. The mixture was heated at 70C inside temperature (95C outside temperature) and thenTriethylamine (120 mL) was added drop wise over one hour and the outside temperature was increased to 125C and maintained. Subsequently, outside temperature increased to 140C, and the inside temperature rose to 130C. A solid clustered at the stirrer, but went back into suspension. Hydrochloric acid vapors evolved.30 mL of triethylamine was added drop wise and then reacted for 1 .5 more hours. A viscous yellowish suspension formed. The product was allowed to cool to 50C inside temperature, then 300 mL water was added and vigorously stirred for 20 minutes and the mixture was transferred to a 2L separatory funnel. Then, the flask was rinsed out with 100 mL of water.The combined aqueous phases were washed twice with 280 mL dichloromethane.The aqueous phase was held at 40C, while KCI was added to the solution until saturated (about 130 g KCI). The mixture was filtered through a fluted filter and stored overnight in a refrigerator.The remaining solid was extracted and dried, resulting in 30.85 g, yield of 17.9%. fl: OH band is present, similar to the precursor.The mother liquor was again treated with KCI and stored (at 35-40C) overnight in the refrigerator.Solid from the second precipitation with KCI was filtered off and dried, resulting in 60.0 g = 34.9 % and the fl corresponds to the desired product.Solid 1: Was boiled with 150 mL EtCH and filtered while hot.By repeated precipitating with KCI, boiling and crystallization, 32 g of the product were obtained for a yield of 19 %.

According to the analysis of related databases, 1562-00-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GEISTLICH PHARMA AG; PFIRRMANN, Rolf W.; (101 pag.)WO2016/98054; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 4152-92-5, Adding some certain compound to certain chemical reactions, such as: 4152-92-5, name is (2-(Aminomethyl)phenyl)methanol,molecular formula is C8H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4152-92-5.

A solution of 1.7 g of 2-(aminomethyl)benzyl alcohol (12. 4 mmol) and 1.76 mL of triethylamine (12. 4 mmol) was dissolved in 20 mL anhydrous methanol, 1.96 mL of ethyl trifluoroacetate (16.4 mmol) was added dropwise under argon and the reaction was stirred at 25 C for 2 hours. After the reaction, ethyl acetate (30 mL) and water (30 mL) were added to the extract. The ethyl acetate layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate overnight, and the solvent was removed in vacuo to give 2-[(trifluoroacetamido)methyl]benzyl alcohol. The crude product was purified by silica gel column chromatography eluting with ethyl acetate / cyclohexane (1: 2, v / v) to give 2-[(trifluoroacetamido)methyl]benzyl alcohol (2.0 g, 8.6 mmol), 69% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4152-92-5, (2-(Aminomethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Beijing University of Technology; Zhao, Lijiao; Sun, Guohui; Zhong, RuGang; (20 pag.)CN104031048; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 4654-39-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Potassium acetate (4.88 g, 49.7 mmol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(l,3,2-dioxaborolane) (7.6 g, 30 mmol) and PdCl2(dppf) (0.91 g, 1.2 mmol) were added to a solution of 2-(4-bromophenyl)ethanol (5.0 g, 25 mmol) in 1,4-dioxane (100 mL) under N2. The mixture was purged with N2 then stirred under N2 at about 85 C for about 12 h. After cooling to rt, water (100 mL) was added and the mixture was extracted with EtOAc (2 chi 100 mL). The combined organic layers were washed with saturated aqueous NaCl (100 mL) and dried over Na2SOzi, filtered and concentrated under reduced pressure. The residue was purified via flash chromatography on silica gel (17% EtO Ac/petroleum ether). The appropriate fractions were collected and concentrated under reduced pressure to give the title compound (6.2 g, 100%). NMR (400MHz, CDC13) delta 7.78 (d, J= 7.9 Hz, 2H), 7.29 – 7.23 (m, 2H), 3.87 (t, J= 6.6 Hz, 2H), 2.90 (t, J= 6.6 Hz, 2H), 1.36 (s, 12H).

According to the analysis of related databases, 4654-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ABBVIE INC.; BREINLINGER, Eric, C.; COX, Phil, B.; DAANEN, Jerome; DIETRICH, Justin; DJURIC, Stevan; DOMBROWSKI, Amanda, W.; FRANK, Kristine, E.; FRIEDMAN, Michael, M.; GOMTSYAN, Arthur; LI, Huan-Qui; LONGENECKER, Kenton; OSUMA, Augustine; ROWLEY, Ann, Marie; SCHMIDT, Robert; VASUDEVAN, Anil; WILSON, Noel; (378 pag.)WO2016/168641; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 575-03-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

According to the analysis of related databases, 575-03-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 25125-21-7, 1-Hydroxymethyl-3-cyclopentene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 25125-21-7, blongs to alcohols-buliding-blocks compound. Recommanded Product: 25125-21-7

To a solution of cyclopent-3-enylmethanol 146-2 (4.0 g, 41 mmol) in dichloromethane (150 mL) at 0C was added 3-chloroperbenzoic acid (10 g, 45 mmol, 77% purity) by portion. The reaction was stirred overnight. Dichloromethane (150 mL) was added. The organics was washed with sodium thiosulfate (12 g in 10 mL water), followed by saturated NaHCCb (40 mL). This was repeated till all the remaining 3-chloroperbenzoic acid was washed away. The organic was dried over MgSC. Evaporation of solvent gave a mixture of cis- and trans- 6- oxabicyclo[3.1.0]hexan-3-ylmethanol 146-3 (2.6 g, 57 %) as a yellow oil. GC-MS: m/z 114 (5) (M+), 95 (15), 88 (100), 81 (15).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,25125-21-7, 1-Hydroxymethyl-3-cyclopentene, and friends who are interested can also refer to it.

Reference:
Patent; ARBUTUS BIOPHARMA CORPORATION; MENDEZ, Patricia; SYMONDS III, William T.; DIETERICH, Douglas; (290 pag.)WO2019/51257; (2019); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 575-03-1 ,Some common heterocyclic compound, 575-03-1, molecular formula is C10H5F3O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The compounds 2a-e and 3a-e were synthesized according to the method from literature [26?28].To a solution of compound 1a-e (10.0 mmol) in acetone (30 mL), 1,2?dibromoethane or1,3-dibromopropane (30.0 mmol) and potassium carbonate (12.3 mmol) were added. The reactionmixture was stirred at 56¡ã C for 10 h, then poured into water, and extracted with ethyl acetate (30 mL x 3).The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,575-03-1, its application will become more common.

Reference:
Article; Tian, Ye; Liang, Zhen; Xu, Hang; Mou, Yanhua; Guo, Chun; Molecules; vol. 21; 6; (2016);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts