Month: March 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Under nitrogen, was added 200mL pyridine 1000ml three-neck flask,120 g BP103a00 (1.0 eq), stirred and cooled to 0 C, 151.8 g of TsCl (1.0 eq) was added in portions, and stirred for 1 h.Then slowly warm to room temperature and continue to stir for 3-4 h.After the reaction is completed, the reaction solution is poured into a dilute hydrochloric acid solution of ice, extracted with EA, and the EA layer is washed once with dilute hydrochloric acid. Washed with saturated sodium bicarbonate, washed with brine, dried over anhydrous Na2SO4, solvent was distilled off under reduced pressure, silica gel column chromatography to give pure BP103a01 55g

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 112-27-6, 2,2′-(Ethane-1,2-diylbis(oxy))diethanol.

Reference:
Patent; Borui Bio-pharmaceutical (Suzhou) Co., Ltd.; Yuan Jiandong; Huang Yangqing; Song Yunsong; (20 pag.)CN109771658; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 1124-63-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1124-63-6, name is 3-Cyclohexylpropan-1-ol. A new synthetic method of this compound is introduced below.

F. 0.2 g of the catalyst prepared in Example 1, 14.2 mg (0.1 mmol) 3-cyclohexyl-1-propanol and 10 mg dodecane as an internal standard were added to 5 ml of 5 mmol (0.43 g) pivalaldehyde in xylene, and the mixture was allowed to react for 4.5 hours under reflux. The product was analyzed by gas chromatography and GC-MS. As a result, the product was identified as 3-cyclohexylpropyl aldehyde. Gas chromatography analysis indicated 45 % yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1124-63-6, 3-Cyclohexylpropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; JAPAN TOBACCO INC.; EP603409; (1994); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 3279-95-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3279-95-6, name is 2-(Aminooxy)ethanol, molecular formula is C2H7NO2, molecular weight is 77.08, as common compound, the synthetic route is as follows.

Method B: To a solution of 2-(2-chloro-4-iodo-phenylamino)-3,4-difluoro-benzoic acid pentafluorophenyl ester (10.0 g, 17.4 mmol) in anhydrous dimethylformamide (36 mL) was added 2-(aminooxy)-ethanol (1.6 g, 20.8 mmol) and N,N-diisopropylethylamine (6.0 mL, 34.8 mmol). The resultant solution was stirred at ambient temperature for 16 h. The reaction mixture was concentrated to 20% volume then diluted with ethyl acetate (360 mL). The resultant solution was washed with water (6*60 mL) and brine (2*60 mL). The organics were dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford a white solid that was purified on silica gel. Elution with ethyl acetate-methanol (9:1) afforded 2-(2-chloro-4-iodo-phenylamino)-3,4-difluoro-N-(2-hydroxy-ethoxy)-benzamide (7.31 g, 90%) as a white solid. Recrystallization from methanol afforded analytically pure material, identical in all respects to the material prepared by method A.

Statistics shows that 3279-95-6 is playing an increasingly important role. we look forward to future research findings about 2-(Aminooxy)ethanol.

Reference:
Patent; Barrett, Stephen Douglas; Biwersi, Cathlin Marie; Chen, Michael Huai Gu; Kaufman, Michael David; Tecle, Haile; Warmus, Joseph Scott; US2004/54172; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 111-41-1, N-(2-Hydroxyethyl)ethylenediamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 111-41-1, blongs to alcohols-buliding-blocks compound. Recommanded Product: N-(2-Hydroxyethyl)ethylenediamine

1), synthesis:To a 500 ml three-necked flask was added 104 g of hydroxyethyl ethylenediamine (1.0 mol), 94.7 g of paraformaldehyde (3 mol, 95%), stirred for 30 minutes, and at room temperature of 80-90 C 156.8 g of formic acid (3 mol, ), About 1 hour dropping end, continue to control the temperature of 80-90 C for 1 hour. 70g (vacuum-0.094MPa, kettle temperature: 80C) was distilled off under reduced pressure. The product was analyzed by gas chromatography at a concentration of 91.8% and 8% of the impurity S-2 (i.e., by-product N, N, N’-trimethyl-N’-ethylidene-ethylenediamine).2), transesterification:100 g of n-butanol was added to the three-necked flask of step 1) and the temperature was raised to 120 C for 4 hours to effect the reaction of the by-product N, N, N’-trimethyl-N’-ethylidene- Ammonia transesterification reaction to produce TMAEEA, by gas chromatography analysis, impurity S-2 content of 0.05%, after cooling back.3), distillation purification:The liquid of step 2) was transferred to a 500 ml rectification flask under reduced pressure at a vacuum of -0.094 MPa, a component at 62 C was n-butanol and a transesterified n-butanolate, 118 C component Ie product TMAEEA. A mixture of 139 g at 118 C was collected, the yield was 95.2% and the content was 99.9%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-41-1, its application will become more common.

Reference:
Patent; Sichuan Zhijiang High-tech Materials Co., Ltd.; Zhang Qi; Zhang Chao; Zhang Hua; Ye Xiaoming; Chen Xinzhi; (7 pag.)CN106748826; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 7073-69-0, 2-(2-Bromophenyl)propan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-(2-Bromophenyl)propan-2-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 2-(2-Bromophenyl)propan-2-ol

A 12-Liter 4-neck round bottom flask equipped with a thermocouple, condenser, addition funnel and overhead mechanical stirrer under dry Argon was charged with anhydrous THF, (3 L) and chilled to -70 to -78 C. via a dry ice/acetone bath. n-Butyl lithium (2.5N in hexanes, 860 mL, 2.15 mol) was slowly added via addition funnel. An exotherm was observed as the temperature rose from -78 to -70 C. To the addition funnel was added a solution of Compound 10d (220 g, 979.97 mmol) in anhydrous THF (1 L). The 2-(2-bromophenyl)propan-2-ol solution was slowly added to the n-BuLi solution. The addition took 90 min in order to maintain a reaction temperature below -70 C. After the addition was complete, the reaction mixture was stirred at -70 to -75 C. for 30 min. The triethylborate (230 mL, 1.35 mol) was quickly added in 3 portions at -70 C. An exotherm was observed, the batch temperature rose from -70 to -64 C. The reaction was stirred at -70 C. and slowly warmed to room temperature over night. After the reaction was cooled to 0-5 C., the reaction was slowly quenched with 2 M HCl (1 L, 2.00 mol) added via the addition funnel while maintaining the batch temperature 0-5 C. The reaction mixture was stirred for 1 h. The aqueous phase pH was 9-10. The pH was then adjusted to acidic (4-5) with 2 M HCl (200 mL). The two phases were separated and the aqueous layer was extracted with MTBE (2¡Á500 mL). The combined organic phases were dried with anhydrous magnesium sulfate. The solution was filtered and concentrated to yield a yellow oil. The yellow oil was diluted with MTBE (1.5 L) and washed with 1M NaOH (3¡Á500 mL). The product containing basic aqueous phases were combined and acidified with 2 M HCl (800 mL) (the clear solution turns turbid with the addition of acid). After stirring the turbid solution for 15 min (pH=4-5) (Note 1), it was extracted with MTBE (2¡Á500 mL). The organic phases were combined and dried over MgSO4. The solution was filtered and the filtrate was concentrated to yield the title Compound 10e as a clear yellow oil (121.78 grams, 77% yield).

The synthetic route of 7073-69-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Player, Mark R.; Dax, Scott L.; Parsons, William H.; Brandt, Michael Richard; Calvo, Raul R.; Patel, Sharmila; Liu, Jian; Cheung, Wing S.; Jetter, Michele C.; Lee, Yu-Kai; Youngman, Mark A.; Pan, Wenxi; Weils, Kenneth M.; Beauchamp, Derek A.; US2007/259936; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 13826-35-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13826-35-2, name is (3-Phenoxyphenyl)methanol, molecular formula is C13H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The liquid phase oxidative methylesterification of various substrates was carried out in a 15 mL glass vial equipped with a magneticstirrer. In a general procedure, 1 mmol of the substrate wasadded to the reaction vial containing 3 mL of dimethyl sulfoxide(DMSO), 1 mL of distilled water and 10 mg of the catalyst. To theresulting mixture, 70% aqueous TBHP (4 mmol 12 mmol) wasadded dropwise under continuous stirring. The addition of TBHPwas exothermic. The reaction vial was sealed with a Teflon septumfitted aluminium cap and immersed in an oil bath maintained at100 C. The reaction was continued for 20 h. After the reaction,the catalyst was isolated by centrifugation and the filtrate wasmixed with 100 mL of water in a 250 mL separating funnel. Theorganic compounds were extracted from the aqueous mixtureusing ethyl acetate (50 mL 2 times). The organic portion wascombined and dried over Na2SO4 and evaporated under vacuumusing a rotator evaporator to obtain the crude product. The crudeproducts were purified by column chromatography using silicagel (100-200 mesh) and a mixture of petroleum ether and ethylacetate. The products were initially identified by GC-MS andfinally confirmed by NMR spectroscopy.

According to the analysis of related databases, 13826-35-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Gupta, Shyam Sunder R.; Kantam, Mannepalli Lakshmi; Vinu, Ajayan; Journal of Catalysis; vol. 389; (2020); p. 259 – 269;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C17H16O3

Example 11.20 g (2.3 mmol) of a naphthol compound represented by the following formula (19) and 0.80 g (3.0 mmol) of a propargyl alcohol compound represented by the following formula (20) were dissolved in 70 ml of toluene, 0.022 g of p-toluenesulfonic acid was further added to the resulting solution, and the obtained mixture was stirred under reflux by heating for 1 hour.After the reaction, the solvent was removed, and the obtained product was purified by chromatography on silica gel to obtain 1.35 g of a white powder product. The yield rate was 76 %.The elemental analysis values of this product were 80.70 % of C, 6.79 % of H and 12.51 % of O which were almost equal to the calculated values of C52H52O6 (C: 80.80 %, H: 6.78%, O: 12.42 %).When the proton nuclear magnetic resonance spectrum of the product was measured, it showed 18H peaks based on the methyl proton of a tetramethylcyclohexane ring and a methylene proton at delta of around 1.0 to 3.0 ppm, a 15H peak based on the methyl proton of a methoxy group at delta of around 2.3 to 4.5 ppm and 19H peaks based on an aromatic proton and the proton of an alkene at delta of around 5.6 to 9.0 ppm. Further, when the 13C-nuclear magnetic resonance spectrum was measured, it showed a peak based on the carbon of an aromatic ring at delta of around 110 to 160 ppm, a peak based on the carbon of an alkene at delta of around 80 to 140 ppm and a peak based on the carbon of an alkyl at delta of around 20 to 60 ppm.It was confirmed from the above results that the isolated product was a compound represented by the following formula (21).

With the rapid development of chemical substances, we look forward to future research findings about 101597-25-5.

Reference:
Patent; Tokuyama Corporation; EP2479171; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4541-14-4, name is 4-(Benzyloxy)butan-1-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C11H16O2

To stirred solution of alcohol 21 (10 g, 55.5 mmol) in dichloromethane (150 mL) at 0 C were added pyridinium chlorochromate (17.96 g, 83.33 mmol) and Celite (17.96 g) and stirred at room temperature for 5 h. Diethyl ether (100 mL) was added and the reaction mixture was filtered through a small pad of Celite and silica gel. The filtered cake was washed thoroughly with ether (2 ¡Á 150 mL) and the filtrate was concentrated under reduced pressure. After flash column chromatography on silica gel (100-200 mesh, eluent: 8% EtOAc in hexane) aldehyde 22 (9.09 g, 92%) was obtained as a colorless liquid. 1H NMR (400 MHz, CDCl3): delta 9.76 (t, J = 1.5 Hz, 1H), 7.36-7.17 (m, 5H), 4.46 (s, 2H), 3.47 (q, J = 5.1 Hz, 2H), 2.53 (td, J = 7.0, 1.5 Hz, 2H), 1.92 (ddd, J = 13.0, 7.0, 6.0 Hz, 2H); 13C NMR (75 MHz, CDCl3): delta 201.3, 138.2, 128.4, 127.6, 73.0, 69.0, 41.0, 22.6; MASS (EIMS): m/z 178 (M)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4541-14-4, 4-(Benzyloxy)butan-1-ol.

Reference:
Article; Venkatesham, Akkaladevi; Nagaiah, Kommu; Tetrahedron Asymmetry; vol. 23; 15-16; (2012); p. 1186 – 1197,12;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 55362-80-6, name is 9-Bromononan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C9H19BrO

To a solution of concentrated nitric acid (10 mL, 258 mmol) 9-bromononanol (1 gr, 4.48 mmol) was added over a period of 30 minutes, maintaining a temperature of 25-30 0C. The solution was stirred at room temperature for 4 hours, then heated to 80 0C and stirred for an additional hour. The reaction mixture was then cooled back to room temperature and diluted carefully with 100 mL of distilled water. The product was extracted with diethyl ether (4×25 mL) after which the organic phases where combined and dried over magnesium sulfate. The mixture was then filtered and concentrated in vacuo to yield product 4a quantitatively. 1H-NMR (200 MHz, CDCl3): 1.3-1.5 (m; 8H), 1.59-1.71 (m; 2H), 1.78-1.92 (m; 2H), 2.36 (t; / = 7.4 Hz ;2H), 3.40 (t; /= 6.8 Hz; 2H), 9.8 (m, IH).

With the rapid development of chemical substances, we look forward to future research findings about 55362-80-6.

Reference:
Patent; NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV; MEIJLER, Michael M.; AMARA, Neri; RAYO, Josep; WO2011/1419; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 4464-18-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4464-18-0, name is Benzene-1,3,5-triyltrimethanol. This compound has unique chemical properties. The synthetic route is as follows.

As asolution A, 16.8 g (0.1 mol) of 1,3,5-tris (hydroxymethyl) benzene and 0.32 g (0.5 mmol) of dibutyltin EGI-1 (2-methacryloyloxyethyloxy) ethyl isocyanate was changed to a solution in which dilaurate was dissolved and the addition amount of 2- (2-methacryloyloxyethyloxy) ethyl isocyanate was changed to 61.8 g (0.31 mol) EGI-6 (76.2 g, yield 99%) was obtained by synthesizing in the same manner as in the synthesis procedure of EGI-6.The dataof1H NMR spectrum ofthe obtained EGI-6were as follows.

According to the analysis of related databases, 4464-18-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOKUYAMA DENTAL CORPORATION; SUZUKI, TAKESHI; SAKATA, EIBU; YAMAGAWA, JUN-ICHIRO; (25 pag.)JP6225054; (2017); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts