Month: March 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 2-(Diethylamino)ethanol

General procedure: 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)cyclopentane-1-carboxylate hydrochlorides 7a-7f were synthesized as described above for 6a-6e from 7 mmol of amino alcohol 5a-5f and 1.87 g (7 mmol) of acid chloride 3 in the presence of 0.7 g (7 mmol) of triethylamine. A solution of 1.3 g (5 mmol) of acid chloride 3 in 30 mL of anhydrous benzene was added with shaking to a mixture of 5 mmol of diamine 4a-4e and 0.5 g (5 mmol) of triethylamine in 50 mL of anhydrous benzene. The mixture was left to stand for 2 h at room temperature and was then refluxed for 10 h. After cooling, the mixture was treated with 3 mL of 15% aqueous sodium hydroxide with shaking, and the organic layer was separated, washed with water until neutral reaction, and dried. The solvent was distilled off, the residue was dissolved in diethyl ether, and a solution of dry HCl in diethyl ether was added. The precipitate was filtered off and recrystallized from ethanol.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Article; Arustamyan, Zh. S.; Markaryan; Aghekyan; Nazaryan; Hakobyan; Paronikyan; Minasyan; Russian Journal of Organic Chemistry; vol. 55; 6; (2019); p. 796 – 799; Zh. Org. Khim.; vol. 55; 6; (2019); p. 896 – 900,5;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 29908-11-0, name is (1,4-Dioxan-2-yl)methanol, the common compound, a new synthetic route is introduced below. Formula: C5H10O3

[0284] An oven dried multineck round bottom flask equipped with a condenser and an inlet septum under N2 is loaded with NaH (1.25 equiv., 60% in mineral oil) and dry THF (2.67 mL/mmol). An alcohol (1.2 equiv.) is added dropwise and the resulting mixture is stirred at room temperature for 20 min and subsequently heated at 50 C for 20 min. Then 4-chloro-6,7-dihydrobenzo[a]quinolizin-2-one derivative is added (1.0 equiv.) as a dry solid to the alkoxide mixture (any material that can not be transferred as such is dissolved in dry THF (1.3 mL/mmol) and added to the mixture). The mixture is briefly purged with N2 and heated at 70 C until all starting material is consumed. The mixture is cooled down to room temperature and quenched with saturated aq. NaHCO3. The mixture is then concentrated in vacuo and partitioned between DCM and brine. The aqueous layer is extracted once with DCM and combined organics are dried over Na2SO4 and concentrated to dryness. The crude product is dissolved in MeCN and refluxed for 15 min. The mixture is cooled down to room temperature and the precipitate is separated by filtration. The precipitate is discarded and the filtrate is washed with pentane. The MeCN phase is concentrated to dryness affording the desired product.

The synthetic route of 29908-11-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GALAPAGOS NV; MENET, Christel, Jeanne, Marie; DOYON, Julien, Georges, Pierre-Olivier; CLAES, Pieter, Isabelle, Roger; ALLART, Brigitte; DE WACHTER, Maxim, Maria, Paul; TRICARICO, Giovanni, Alessandro; (168 pag.)WO2016/169911; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 1072-52-2, Adding some certain compound to certain chemical reactions, such as: 1072-52-2, name is 2-(Aziridin-1-yl)ethanol,molecular formula is C4H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1072-52-2.

Into a dry 500 mL distillation flask there was placed 91 mL (1.14 mole) of aziridineethanol to which there was added 495 mg of NaH (60% dispersion in mineral oil). The mixture was stirred for 30 min and the flask was vented. Dimethyl adipate (48 mL, 0.29 mole) was added to the mixture and the flask was connected to a distillation column. The resulting mixture was then heated and methanol was removed at reduced pressure during a period of one hour. Excess aziridineethanol was then removed by heating the mixture to 70 C at a pressure of 0.15 mm Hg. The desired product was then distilled off from the mixture at 130 C at a pressure of 0.15 mm Hg to obtain 49 g (0.18 mole, 60% yield) of di[2-(1-aziridinyl)ethyl]adipate as a colorless oil having the following analysis: 1H NMR (400 MHz, DMSOd6) delta=1.10-1.11(m, 4H, CH2). 1.51-1.55(m, 8H, CH2), 2.28-2.35(m, 8H, CH2), 4.09(t, J=4.0 Hz, 4H, CH2) ppm. 3C NMR (100 MHz, DMSOd6) delta=24.6; 27.0; 33.8; 59.7; 64.2; 173.3 ppm IR: 3064.42; 2952.38; 1731.46; 1454.54; 1264.33; 1174.82 cm-1

According to the analysis of related databases, 1072-52-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Gianolio, Diego A.; Calias, Pericles; Miller, Robert J.; US2005/222081; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 61487-25-0, Adding some certain compound to certain chemical reactions, such as: 61487-25-0, name is (2-Amino-3-chlorophenyl)methanol,molecular formula is C7H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61487-25-0.

EXAMPLE 82 Preparation of 2-chloro-6-methoxymethylaniline A solution of 4.00 g (25.4 mmol) of 2-amino-3-chlorobenzyl alcohol in 30 ml of dry THF was cooled to -78 C., treated with 16.7 ml (26.7 mmol) of 1.60M n-butyllithium in hexane, warmed to 0-5 C., treated with 3.61 g (25.4 mmol) of methyl iodide and heated at reflux for 5.5 hours. The solvent was removed by evaporation at reduced pressure. The residue was partitioned between 175 ml of ether and water, and the organic phase was separated and dried (MgSO4). The solvent was removed by evaporation at reduced pressure, and the residue was purified by HPLC eluding with ETOAc (5:95, v/v) to afford 1.1 g of the desired product as a pale brown oil. IR and 1 H NMR spectra were in agreement with the assigned structure. Analysis: Calculated for C8 H10 ClNO: C, 56.00; H, 5.87; N, 8.16; Found: C, 56.25; H, 5.98; N, 8.28.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 61487-25-0, (2-Amino-3-chlorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The Dow Chemical Company; US4755212; (1988); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 53463-68-6, 10-Bromodecanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 53463-68-6, blongs to alcohols-buliding-blocks compound. COA of Formula: C10H21BrO

DHP (6 mL, 65.82 mmol) and PPTS (127 mg, 0.50 mmol) were added to a solution of bromo-alcohol (12 g, 50.63 mmol) in 100 mL of CH2Cl2 and the mixture was stirred for 16 h. The reaction mixture was quenched with 2 M Na2CO3 solution and extracted with CH2Cl2. The organic layer was dried over Na2SO4, concentrated under reduced pressure. Purification by flash column (6percent EtOAc/hexanes) yielded 16 (14.9 g, 92percent) as a colorless oil. Rf=0.65 (10percent EtOAc/hexanes); 1H NMR (500 MHz, CDCl3): delta 4.54 (dd, J=3.9, 2.9 Hz, 1H), 3.83 (ddd, J=11.7, 8.7, 2.9 Hz, 1H), 3.69 (dt, J=9.7, 6.8 Hz, 1H), 3.47 (m, 1H), 3.36 (m, 3H), 1.81 (m, 3H), 1.67 (m, 1H), 1.53 (m, 6H), 1.39 (m, 2H), 1.28 (m, 10H); 13C NMR (75 MHz, CDCl3): delta 98.7, 67.5, 62.2, 33.9, 32.7, 30.6, 29.6, 29.3, 29.2, 28.6, 28.0, 26.1, 25.4, 19.5; IR (neat): numax 2924, 2855, 1454, 1354, 1126, 1072, 1028 cm?1; HRMS (ESI): calcd for C15H29O2NaBr [M+Na]+ 343.1248; found 343.1251.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,53463-68-6, its application will become more common.

Reference:
Article; Kadam, Vilas D.; Sudhakar, Gangarajula; Tetrahedron; vol. 71; 7; (2015); p. 1058 – 1067;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110-73-6, name is 2-(Ethylamino)ethanol, the common compound, a new synthetic route is introduced below. Recommanded Product: 110-73-6

The synthesis of INI-12 : [Show Image] 8 g (26 mmol) 2-(3-chloropropoxy)-9H-thioxanthen-9-one was dissolved in 80 mL acetonitrile. The mixture was heated to reflux and 13.2 mL (130 mmol) 2-(ethylamino)-ethanol was added. The reaction was allowed to continue for 24 hours at reflux. 0.7 g sodium iodide was added and the reaction was allowed to continue for another 24 hours at reflux. The precipitated salts were removed by filtration and the solvent was removed under reduced pressure. The residue was dissolved in 150 mL t.butyl methyl ether and extracted 4 times with 100 mL 0.1 N hydrochloric acid. The aqueous fractions were pooled and the pH was adjusted to 12, using a 5 N NaOH solution. The mixture was extracted with 200 mL t.butyl methyl ether. The organic fraction was dried over MgSO4 and evaporated under reduced pressure. 7.6 g (82 %) of the intermediate was isolated.

The synthetic route of 110-73-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AGFA Graphics NV; EP2130817; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2566-44-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2566-44-1, name is 2-Cyclopropylethanol, molecular formula is C5H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-Cyclopropylethanol, (21.35 g, 248 mmol, Lancaster), imidazole (25.32 g, 372.4 mmol, Aldrich), and [TRIPHENYLPHOSPHINE] (84.64 g, 323 mmol, Aldrich) were dissolved into methylene chloride (300 mL). The resulting mixture was cooled to [0C] in an ice bath. Afterward, iodine (75.37 g, 298 mmol, Aldrich) was added portion- wise such that the temperature remained at less than [30C.] After this addition was complete, the mixture was allowed to warm to ambient temperature and mix under N2 overnight. The mixture was then diluted with deionized water (250 mL). Subsequently, the layers were separated. The methylene chloride layer was washed with 200 mL each of 10% HCl (aq) (200 mL), saturated [NAHC03 (AQ)] (200 mL), and 10g Na2S203 in deionized water (200 mL). The methylene chloride layer was dried over [MGS04,] filtered, and concentrated in vacuo with a rotovap having a bath temperature of less than [25C] to form solids. Hexanes (150 mL) were added to the solids, and the mixture was slurried for approximately [LHR.] The solids were-then filtered and washed with hexanes (150 mL). The filtrate was passed through a pad of silica (pre-washed with hexanes), with the silica being washed with hexanes to elute the product through the silica. Five bulk fractions of 350 mL each were taken. Product was detected in the first 3 fractions, and had little [TRIPHENYLPHOSPHINE] contamination. Those fractions were combined and concentrated in vacuo with a [ROTOTRAP] having a bath temperature of less than [25C] to form 30.08 g of an oil (62% [YIELD). 1H] NMR was consistent with the desired cyclopropyl ethyl iodide intermediate product.

According to the analysis of related databases, 2566-44-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PHARMACIA CORPORATION; WO2004/811; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 7589-27-7, Adding some certain compound to certain chemical reactions, such as: 7589-27-7, name is 2-(4-Fluorophenyl)ethanol,molecular formula is C8H9FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7589-27-7.

Step 1: Preparation of 1-(2-bromoethy -4-fluorobenzenePhosphorus tribromide (19.3 g, 71.3 mmol) was added slowly into a solution of 2-(4- fluorophenyl)ethanol (5.0 g, 35.7 mmol) in hexane at 0 ‘C. After 12 hours under stirring, the reaction mixture was diluted with a 10% aqueous solution of NaHC03 and ethyl acetate. The organic layer was washed with water and brine, dried (Na2S04) and concentrated under vacuum to give the title compound (5.7 g, 78 %). TLC: ethylacetate/ Hexane (3/7): R, : 0.85. 1H NMR (CDCI3, 400 MHz): delta 7.20-7.16 (m, 2H), 7.03-6.99 (m, 2H), 3.56 (t, J=7.40 Hz, 2H), 3.15 (t, J=7.44 Hz, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7589-27-7, 2-(4-Fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARES TRADING S.A.; JORAND-LEBRUN, Catherine; SWINNEN, Dominique; GERBER, Patrick; KULKARNI, Santosh; WO2012/130915; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 4277-34-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4277-34-3 as follows.

(E)-2-Cyanoethyl cyclooct-4-enyl diisopropylphosphoramidite (2). To a solution of (E)-Cyclooct-4-enol (70 mg, 0.56 mmol) in 2 ml of absolute CH2Cl2 under argon diisopropylethylamine (0.33 ml, 1.90 mmol) was added. The mixture was cooled to 0C and 2-cyanoethyl-N,N-diisopropylchlorophosphoramidite (141 mul, 0.63 mmol, 1.05 eq) was added. After stirring for one hour at RT, the reaction mixture was directly loaded on a silica column. Purification by flash chromatography (hexane/ethyl acetate 95:5) yielded the product as colourless oil (100 mg, 0.31 mmol, 55%). 1H-NMR (500 MHz, CDCl3, 25C, TMS): delta = 1.16-1.19 (m, 12H), 1.55-1.63 (m, 2H), 1.86-2.37 (m, 8H), 2.63 (t, J = 6.55 Hz, 2H), 3.51-3.61 (m, 3H), 3.72-3.85 (m, 2H), 5.38-5.44 (m, 1 H), 5.54-5.61 (m, 1H). 13C {1H, 31P} NMR (75 MHz, CDCl3, 25C, TMS): delta=20.3, 24.4, 24.6, 31.1, 31.3, 32.7, 32.8, 34.4, 40.0, 40.3, 42.9, 43.0, 43.2, 58.1, 58.3, 79.6, 80.0, 117.6, 132.6, 135.1, 135.2. 31P-NMR (121 MHz, CDCl3,25C, H3PO4): delta=145.5, 146.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4277-34-3, its application will become more common.

Reference:
Patent; Deutsches Krebsforschungszentrum; Ruprecht-Karls-Universitaet Heidelberg; Schoch, Juliane; Jaeschke Andres; Samanta, Ayan; Wiessler, Manfred; EP2565199; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 39590-81-3 , The common heterocyclic compound, 39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane, molecular formula is C5H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation 22 Synthesis of [l-({[t-butyl (diphenyl) silyl] oxy} methyl) cyclopropylmetbanol Lithium aluminum hydride (LAH) 15.3g was dissolved in 39g of tetrahydrofuran, and 11.7g of the carboxylic acid prepared in Preparation 21 was slowly added dropwise at OIT. The reaction solution was refluxed for 17 hours. The reaction was stopped by adding 10% HCl at room temperature and the mixture was extracted with ethyl acetate. The extract was distilled under reduced pressure and the residue was purified by silica gel column to give 8.2g of diol compound. ‘H NMR (CD3) 6 0.56 (s, 4H), 2.22 (s, 2H), 3.63 (s, 4H) The compound thus obtained (400mg) was dissolved in 12mNo. of THF, 184mg of NaH and 1. 16g of t-butyldiphenylsilylchloride (TBDPSCI) were added, and the resulting mixture was refluxed for 6 hours. The reaction was stopped by adding I OmUSD of water and the mixture was extracted with ethyl acetate, The extract was distilled under reduced pressure and the residue was purified by silica gel column to give l. lg of the title compound. 1H NMR(CDCl3) No. 0.33 (t, 2H), 0. 48 (t, 2E9, 1.23 (s, 9H), 3.59 (d, 4H), 7.42 (m, 6H), 7.68

The synthetic route of 39590-81-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ANADYS PHARMACEUTICALS, INC.; WO2005/79812; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts