Month: March 2021

Adding a certain compound to certain chemical reactions, such as: 23783-42-8, 2,5,8,11-Tetraoxatridecan-13-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 23783-42-8, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

To a stirred solution of triethyl amine (4.368 g, 40 mmol) and 2,5,8, 1 l-tetraoxatridecan-l3-ol (4.165 g, 20 mmol) in dichloromethane (30 mL) was added methanesulfonyl chloride (4.165 g, (0286) 20 mmol, diluted in 20 ml of dichloromethane) dropwise over 30 minutes at 0 C. The reaction was then stirred at room temperature overnight. Water (40 mL) was next added to the reaction. It was extracted with dichloromethane (3x 150 mL), and the organic phase was washed with 0.3 N HC1 (2×80 mL) and water (3 x 100 mL). After drying with NaiSOr. removal of the solvent provided the title compound (5.507 g, 96% yield). NMR (500 MHz, DMSO-riri) d: 4.33-4.29 (m, 2H), 3.70-3.64 (m, 2H), 3.59-3.49 (m, 10H), 3.45-3.42 (m, 2H), 3.24 (s, 3H), 3.17 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,23783-42-8, its application will become more common.

Reference:
Patent; ZHEJIANG VIMGREEN PHARMACEUTICALS, LTD; SUN, Sanxing; ZHAO, Long; HU, Chongbo; CHEN, Zhengshu; YE, Jinqi; (0 pag.)WO2020/2969; (2020); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 627-30-5, 3-Chloropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 627-30-5, blongs to alcohols-buliding-blocks compound. SDS of cas: 627-30-5

A mixture of 3-chloro-1-propanol (10 g), and sodium azide (13.7 g) in water (50 mL) was heated at 90 C. overnight. Compound 3 was obtained by ether extraction

At the same time, in my other blogs, there are other synthetic methods of this type of compound,627-30-5, 3-Chloropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Life Technologies Corporation; Yue, Stephen; Huang, Shih-Jung; Bradford, Jolene; US8999965; (2015); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 558-42-9, name is 1-Chloro-2-methyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C4H9ClO

Example 2A4-(2-Hydroxy-2-methylpropoxy)benzaldehyde5.00 g (40.94 mmol) of 4-hydroxybenzaldehyde, 4.44 g (40.94 mmol) of 1-chloro-2-methyl-2-propanol and 6.08 g (57.32 mmol) of sodium carbonate are initially charged in 50 ml of dry DMF and stirred under reflux for 24 h.After cooling to RT, 20 ml of ethyl acetate and 20 ml of sat. aqueous sodium bicarbonate solution are added.The phases are separated, and the organic phase is dried over magnesium sulfate.After removal of the solvent, the residue is purified by column chromatography on silica gel 60 (mobile phase gradient: cyclohexane/ethyl acetate 5:1?1:1).This gives a reddish solid which is used without further purification for the subsequent step.Yield: 4.40 g (50percent of theory, 90percent purity)LC-MS (method 2): Rt=1.37 min; MS (ESIpos): m/z=195 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 558-42-9, 1-Chloro-2-methyl-2-propanol.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2011/130377; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 30595-79-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30595-79-0, name is 2,6-Dichlorophenethyl alcohol, molecular formula is C8H8Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 3: To a solution of 2-(2,6-dichlorophenyl)ethanol (37.3 g, 195 mmol) and TEA (32.7 g, 235 mmol) in DCM (700 mL) was added MsCI (26.9 g, 235 mmol) dropwise at 0C. After addition, the solution was stirred at rt overnight, diluted with water (200 mL) and extracted with DCM (3 x 400 mL). The combined organic layer was dried over Na2S04, filtered, concentrated and purified by flash chromatography (PE/EtOAc = 5:1 ) to afford 2,6-dichlorophenethyl methanesulfonate lnt-1 c- 11. 1H-NMPi (300 MHz, CDCI3): delta 2.95 (s, 3H), 3.43 (t, J = 7.5 Hz, 2H), 4.41 (t, J = 7.5 Hz, 2H), 7.12-7.17 (m, 1 H), 7.31 (d, J = 8.4 Hz, 2H)

According to the analysis of related databases, 30595-79-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GILEAD SCIENCES, INC.; KINZEL, Olaf; KREMOSER, Claus; SCHMITT, Aaron C.; GEGE, Christian; (205 pag.)WO2016/96115; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 2568-33-4 , The common heterocyclic compound, 2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of compound la (4 g, 38 mmol) in DMF (30 mL) was added NaH (3.3 g,8.4 mmol, 60% in mineral oil) at 0C over 10 mins. The mixture was stirred for half an hour atr.t., and then cooled to 0 C. Then compound 7-1 (6 g, 32 mmol) in DMF (20 mL) was added to5 the reaction, and the reaction was stirred at r.t. for 12 h. The reaction was poured into water(100 mL), and the resulting mixture was stirred for 10 min. The mixture was then was extractedwith EtOAc (60 mL x 3). The organic layers were combined, washed with water (60 mL), brine( 60 mL ), dried and concentrated to give crude product, which was used directly for the next stepwithout further purification. MS (ESI) m/z: 274.1.

The synthetic route of 2568-33-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; HAGMANN, William K.; NARGUND, Ravi P.; BLIZZARD, Timothy A.; JOSIEN, Hubert; BIJU, Purakkattle; PLUMMER, Christopher W.; DANG, Qun; LI, Bing; LIN, Linus S.; CUI, Mingxiang; HU, Bin; HAO, Jinlai; CHEN, Zhengxia; WO2014/19186; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2566-44-1 ,Some common heterocyclic compound, 2566-44-1, molecular formula is C5H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a sealed tube, 2-(tributylphosphoranylidene)-acetonitrile (7.30 g, 30.25 mmol) was added to a solution of 5-Methyl-3-nitro-lH-pyrazole (2.00 g, 15.74 mmol) and 2- cyclopropylethanol (2.04 g, 23.68 mmol) in toluene (70 mL). The mixture was heated at 60 C for 19 h. After cooling down to rt, the mixture was diluted with EtOAc and water. The organic layer was decanted and the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel (Irregular SiOH, 20-45 muiotaeta, 40 g, mobile phase: heptane/EtOAc, gradient from 60:40 EtOAc to 50:50). The pure fractions were combined and the solvent was evaporated until dryness to give 2.10 g of intermediate 232′ (68% yield) and 330 mg of intermediate 232 (11% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2566-44-1, 2-Cyclopropylethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier, Alexis, Georges; LIGNY, Yannick, Aime, Eddy; GROSS, Gerhard, Max; JACOBY, Edgar; MEERPOEL, Lieven; GREEN, Simon, Richard; HYND, George; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; (472 pag.)WO2018/2217; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 311-86-4 ,Some common heterocyclic compound, 311-86-4, molecular formula is C3H4BrF3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of 1-[1-(3-azetidin-3-yl-5-chloro-2-methoxy-4-methylphenyl)ethyl]-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine dihydrochloride (20 mg, 0.04 mmol, chiral intermediate from peak 1 of Example 1, step 7) and triethylamine (19 muL, 0.13 mmol) in acetonitrile (0.6 mL) was added 2-bromo-3,3,3-trifluoropropan-1-ol (from Synquest Labs, 9.2 mg, 0.048 mmol). N,N-dimethylformamide (0.3 mL) was added, which created a clear solution that was stirred at 70 C. overnight. The mixture was diluted water and purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 6.6 mg (30%) of the desired product. The product was isolated as a mixture of diastereomers. LCMS calculated for C22H27ClF3N6O2 (M+H)+: m/z=499.2; Found: 499.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; INCYTE CORPORATION; Li, Yun-Long; Yao, Wenqing; Combs, Andrew P.; Yue, Eddy W.; Mei, Song; Zhu, Wenyu; Glenn, Joseph; Maduskuie, JR., Thomas P.; Sparks, Richard B.; Douty, Brent; US2013/59835; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 3513-81-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3513-81-3, name is 2-Methylenepropane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

Step lb : Compound of formula 1-3: R_ = H and Rl = t-Bu :; To a solution of 2-methylene-1, 3-propane diol (5. 28g, 0.06 mmol) and di-tert-butyl dicarbonate (35 g, 0.16 mol) in 150 ml of dichloromethane was added 6N NaOH (70 ml) and tetrabutylammoniahydrogensulfate (3.4 g, 10 mmol). The mixture was stirred at room temperature overnight. The organic layer was separated, washed with NaHC03 (200 ml x 3) and brine (200 ml), dried over anhydrous MgSO4, concentrated and dried over vacuum to give the title compound. ‘H NMR (CDC13) : 5. 20 (s, 2H) ; 4.44 (s, 4H) ; 1.18 (s, 18H). 13C NMR (CDCl3) : 8 153. 3, 138. 5,117. 3,82. 3,66. 9,27. 8.

According to the analysis of related databases, 3513-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; WO2003/97659; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 110-73-6, 2-(Ethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

The compound represented by the above formula (4) 20.3-parts, 60 parts sulfolane and 2-(ethylamino)ethanol (Tokyo Kasei Kogyo Co., Ltd.) 17.8 parts, were placed in a four-necked 200ml flask, and the mixture was stirred for 3 h at 80 C. When the liquid temperature of the reaction solution had fallen to 30 C, the reaction mixture was poured into 20% aqueous sodium chloride solution, and 35% hydrochloric acid was added to set the pH to 6. The precipitated crystals were collected by filtration, washed, and dried, dye intermediate represented by the following formula (101) was obtained, 22.3 parts.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,110-73-6, 2-(Ethylamino)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; NIPPON KAYAKU COMPANY LIMITED; MIFUJI, AKIHIRO; OHTANI, KOHEI; (19 pag.)JP2016/65219; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 3376-59-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3376-59-8, name is 2,3-Dihydroxypropyl benzoate. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred suspension of sodium hydride (0.273 g, 0.68mol, 60% in oil) in anhydrous THF (100 mL) under a nitrogenatmosphere at 0C, a solution of (¡À)-1 (33.3 g, 0.17 mol)in anhydrous THF (150 mL) was added over a period of 1 hmaintaining the internal temperature below 5C. After stirringat room temperature for 12 h, 1-bromotetradecane(187.7 g, 0.68 mol) was added at 0C over a period of 1 h.After complete addition, the reaction mixture was stirred for2 h at room temperature and this was gradually increasedwhen reaching reflux, and then stirred for 24 h. A LiOH solution(10% wt/v,100 mL) was added, and stirring and thetemperature were maintained for 12 h. The mixture was dilutedwith saturated ammonium chloride (300 mL). Theaqueous layer was extracted with dichloromethane (700 mL),washed with water (3 150 mL), and dried over Na2SO4.The unreacted 1-bromotetradeane was removed by distillationunder reduced pressure (1 mm of Hg and 125 C). Theresidue was purified by column chromatography eluting withhexane to obtain (¡À)-2 (39.5 g, 48%) as a white solid, mp.43-45 C (lit. 42.5-43.5C) [18]. 1H NMR (CDCl3, 200MHz) 0.87 (t, J = 6.7 Hz, 6H, C12-C12H3), 1.25 (br s, 44H,C11-C11H2), 1.58-1.61 (m, 4H, C10-C10H2), 3.37-3.73(m, 9H; C9-C9-C3-C2H2, C1H); 13C NMR (CDCl3,200MHz) 14.1 (C16-16), 22.8 (C15-15), 27.6 (C12-12),29.1-29.5 (C13-13), 29.7 (C11-11), 32.5 (C14-14), 32.8(C10-10), 64.3 (3C), 65.5 (C1), 71.0 (C9), 70.9(C9),72.0(C3), 78.4 (C2). EI-LR-MS, m/z, M+: 484.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3376-59-8, 2,3-Dihydroxypropyl benzoate.

Reference:
Article; Rustoy, Eduardo M; Dana, Alejandro; Letters in Organic Chemistry; vol. 13; 1; (2016); p. 71 – 75;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts