Month: March 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 929-06-6, name is 2-(2-Aminoethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-(2-Aminoethoxy)ethanol

Part A A solution of 2-(2-aminoethoxy)ethanol (29.0 g, 0.276 mol) in 180 mL of tetrahydrofuran (THF), under N2, was cooled to 0 C. and treated with 140 mL of 2N NaOH solution. A solution of di-tert-butyl dicarbonate (60.2 g, 0.276 mol) in 180 mL of THF was then added dropwise over 1 h to the rapidly stirred solution. The reaction mixture was then allowed to warm to room temperature and was stirred an additional 18 h. The THF was then removed under reduced pressure and the remaining aqueous slurry was brought to pH 3 by addition of 150 mL of 1M H2SO4 solution. This was then extracted with ethyl acetate (300 mL, 100 mL) and the combined organic layers were washed with H2O (2*) and brine. The organic portion was dried over Na2SO4 and concentrated to give tert-butyl 2-(2-hydroxyethoxy)ethylcarbamate as a colorless oil (47.1 g).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 929-06-6, 2-(2-Aminoethoxy)ethanol.

Reference:
Patent; Crooks, Stephen L.; Griesgraber, George W.; Heppner, Philip D.; Merrill, Bryon A.; US2003/130518; (2003); A1;; ; Patent; Crooks, Stephen L.; Griesgraber, George W.; Heppner, Philip D.; Merrill, Bryon A.; Roberts, Ralph R.; Wei, Ai-Ping; US2003/139441; (2003); A1;; ; Patent; Crooks, Stephen L.; Griesgraber, George W.; Heppner, Philip D.; Merrill, Bryon A.; US2003/187016; (2003); A1;; ; Patent; 3M Innovative Properties Company; US6677347; (2004); B2;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C9H11BrO

In a 250mL three-neck bottle,Under the protection of nitrogen,Add 0.03 mol of dibenzofuran-3-amine,0.04 mol of 2-(2-bromophenyl)propan-2-ol,150mL toluene was stirred and mixed,Then add 0.05 mol of sodium t-butoxide,0.0015mol Pd2 (dba)3,0.0015 mol of tri-tert-butylphosphine, heated to 115 C,Reflow reaction for 24 hours;Naturally cooled to room temperature, filtered, and the filtrate was subjected to vacuum distillation (-0.09 MPa, 85 C), and passed through a neutral silica gel column.Obtaining 2-(2-(dibenzofuran-3-ylamino)phenyl)propan-2-ol;

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7073-69-0, 2-(2-Bromophenyl)propan-2-ol.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Miao Kangjian; Zhang Zhaochao; Zhang Xiaoqing; Li Chong; (48 pag.)CN108203428; (2018); A;,
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Synthetic Route of 1805-32-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of the substrate (1 mmol), HMDS (1 mmol) and PC-NPs (20 mg), in acetonitrile (3 mL), was refluxed at 75 C. After completion of the reaction (monitored byTLC using a 1:1 mixture of EtOAc/n-hexane), the mixture was filtered and the residue was washed with acetonitrile (5 mL). Evaporation of the solvent gave almost the pure product(s). Further purification was proceeded by bulb-to-bulb distillation under reduced pressure or recrystallization to afford the pure silyl ether.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1805-32-9, 3,4-Dichlorobenzyl alcohol.

Reference:
Article; Shirini, Farhad; Fallah-Shojaei, Abdollah; Abedini, Masoumeh; Samavi, Laleh; Journal of the Iranian Chemical Society; vol. 13; 9; (2016); p. 1699 – 1712;,
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Reference of 13330-96-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13330-96-6, name is 4-(Dimethylamino)butan-1-ol, molecular formula is C6H15NO, molecular weight is 117.19, as common compound, the synthetic route is as follows.

(R)-3-[N’-(5-Acetyl-2H-pyrazole-3-carbonyl)-N-(5′-chloro-2′-fluorobiphenyl-4-ylmethyl)-hydrazino]-2-hydroxypropionic Acid 4-dimethylaminobutyl Ester (R)-3-[N’-(5-Acetyl-2H-pyrazole-3-carbonyl)-N-(5′-chloro-2′-fluorobiphenyl-4-ylmethyl)-hydrazino]-2-hydr oxypropionic acid (10.0 mg, 21 mumol) was combined with HOBt (17.1 mg, 126 mumol) and EDC (22 muL, 130 mumol) in DCM (0.2 mL, 3 mmol) and stirred for 10 minutes. 4-Dimethylamino-1-butanol (22.4 muL, 168 mumol) was added and the resulting mixture was stirred at room temperature and monitored for completion (?4 hours). The mixture was concentrated by rotary evaporation and the residue was purified by preparative HPLC to yield the title compound as a TFA salt (4.2 mg). MS m/z [M+H]+ calc’d for C28H33ClFN5O5, 574.22. found 574.1.

The chemical industry reduces the impact on the environment during synthesis 13330-96-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Hughes, Adam D.; Fleury, Melissa; US2013/330365; (2013); A1;,
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Synthetic Route of 57772-50-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.57772-50-6, name is (2-Amino-3-methylphenyl)methanol, molecular formula is C8H11NO, molecular weight is 137.18, as common compound, the synthetic route is as follows.

General procedure: To an oven-dried 15 mL sealed tube were added 2-aminophenylmethanol 1 (0.425 mmol), benzonitrile 2(0.25 mmol), Ru cat. b (1.94 mg, 1 mol%), and KOtBu (14.02 mg, 0.5equiv) intamyl alcohol (1 mL) under an air atmosphere. The sealedtube was capped and heated at 130C for 2 h. The reaction mixturewas cooled down to room temperature and directly concentratedunder vacuum. The crude mixture was puried by preparative thin-layer-chromatography (petroleum ether/ethyl acetate 20/1) togive the desired product 3 or 4.

Statistics shows that 57772-50-6 is playing an increasingly important role. we look forward to future research findings about (2-Amino-3-methylphenyl)methanol.

Reference:
Article; Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji; Tetrahedron; vol. 75; 18; (2019); p. 2697 – 2705;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2807-30-9, name is 2-Propoxyethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Propoxyethanol

10 g of the remaining bottoms of the distillation and 100 g of 2-n-propoxyethanol, 0.05 g of 4-pyrrolidinopyridine was charged into a reaction vessel equipped with a reflux condenser, Example 3 was carried out Distillation yielded 10 g of the preceding distillation and 123.8 g of thionyl chloride (Content 98.8%, sulfuryl chloride content 0.4%) were mixed,The stirring was started, and the mixture was slowly added dropwise to the reaction vessel. The procedure was as in Example 2. After completion of the dropping, heating was started, and the temperature was gradually raised to 98 C according to the reaction gas evolution rate.Until no gas release, continue to heat 4h get crude; The crude product was directly purified by distillation to obtain 116.41g of chloroethyl n-propyl ether. The product chromatogram was 99.2% and the water content was 0.15%. The yield was 98.9%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2807-30-9, 2-Propoxyethanol.

Reference:
Patent; Shandong Kaisheng New Materials Co.,Ltd.; Zhang, Taiming; Wang, Ronghai; Zhang, Qingxin; Zhang, Shanmin; Sun, Fengchun; Bi, Yixia; (6 pag.)CN105384612; (2016); A;,
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Reference of 7541-49-3 , The common heterocyclic compound, 7541-49-3, name is 3,7,11,15-Tetramethylhexadec-2-en-1-ol, molecular formula is C20H40O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Product obtained by hydrogenating phytol. To a solution of phytol (30.00 g, 101.20 mmol) in THF (450 mL) in argon is added platinum dioxide (PtO2, 1.15 g, 6.61 mmol). The medium is placed under 1 bar of dihydrogen then stirred for 4 h at ambient temperature. After filtration under celite by rinsing with THF, a black oil of molecule 47 is obtained after concentration under reduced pressure. Yield: 29.00 g (96%) 1H NMR (CDCl3, ppm): 0.84 (6H); 0.86 (6H); 0.89 (3H); 1.00-1.46 (22H); 1.46-1.68 (3H); 3.61-3.73 (2H).

The synthetic route of 7541-49-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ADOCIA; CHAN, You-Ping; GEISSLER, Alexandre; NOEL, Romain; ROGER, Walter; CHARVET, Richard; LAURENT, Nicolas; (80 pag.)US2019/275115; (2019); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1883-32-5, name is 2,2-Diphenylethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2,2-Diphenylethanol

(3) Preparation of 2,2-diphenylethyl methanesulfonate In a 500 mL three-opening flask, 2,2-diphenyl ethanol (17 g, 86 mmol) was dissolved in 170 mL dichloromethane. To the flask was added triethylamine (13.03 g, 129 mmol). The resulting mixture was stirred at 0 C. for half an hour. To the resulting mixture was slowly added MsCl (11.92 g, 104 mmol) dropwisely. The reaction was conducted at 25 C. After the completion of reaction monitored by TLC, the reaction solution was washed with water thrice. The organic phase was dried over anhydrous sodium sulfate and evaporated to remove the solvent to produce 2,2-diphenylethyl methanesulfonate (23 g) in a yield of 96.78%.

With the rapid development of chemical substances, we look forward to future research findings about 1883-32-5.

Reference:
Patent; XUANZHU PHARMA CO., LTD.; Zhang, Hui; Fan, Mingwei; Sun, Liang; US2014/45896; (2014); A1;,
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Reference of 1611-56-9, Adding some certain compound to certain chemical reactions, such as: 1611-56-9, name is 11-Bromoundecan-1-ol,molecular formula is C11H23BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1611-56-9.

To a solution of 1-bromoundecanol 1 (30 g, 119.4 mmol) in DMF (150 ml_) was added NaN3 (15.5 g, 238.9 mmol) and the resulting mixture was stirred at 70 C for 12 h. The mixture was cooled to 23 C, filtered and the filtrate extracted with hexane (5 x 200 ml_). The hexanes fractions were combined and washed with H20 (2 x 100ml_), dried over anhydrous Na2S04 and concentrated under reduced pressure to afford 11-azidoundecan-1-ol 2 (24.19 g, 95%) as a colorless oil. 1H NMR (CDCI3) delta 3.62 (t, J = 6.6 Hz, 2H), 3.24 (t, J = 6.9 Hz, 2H), 1.61 -1.51 (m, 4H), 1.39-1.24 (m, 14H); 13C NMR (CDCI3) delta 63.15, 51.60, 32.89, 29.66, 29.56, 29.51 , 29.25, 28.95, 26.82, 25.84.

According to the analysis of related databases, 1611-56-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; RHODIA OPERATIONS; UNIVERSITY OF PENNSYLVANIA; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.); DONNIO, Bertrand; JISHKARIANI, Davit; DIROLL, Benjamin, T.; HOUGH, Lawrence; MURRAY, Christopher; CARGNELLO, Matteo; MALASSIS, Ludivine; (83 pag.)WO2016/201310; (2016); A1;,
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Reference of 1261524-75-7, Adding some certain compound to certain chemical reactions, such as: 1261524-75-7, name is 3-Bromo-2-chlorobenzyl Alcohol,molecular formula is C7H6BrClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1261524-75-7.

To (3-bromo-2-chlorophenyl)methanol (CAS 1261524-75-7) (0.253 g, 1.142 mmol) in DCM (1 1.4 mL) at 0 C was added TEA (0.398 mL, 2.86 mmol) followed by MsCI (0.134 mL, 1.713 mmol) and the ice bath was removed and the solution was allowed to stir at room temperature for 30 minutes. At this point, the reaction was placed in an ice bath and diluted with DCM and a saturated solution of sodium bicarbonate. This mixture was passed thorugh a phase separator to remove the water layer. The organics were dried and concentrated to obtain the title compound. 1H NMR (400 MHz, DMSO-c/6) delta ppm 7.85 (dd, J=8.07, 1.47 Hz, 1 H) 7.63 (dd, J=7.70, 1.47 Hz, 1 H) 7.37 (t, J=7.83 Hz, 1 H) 5.37 (s, 2 H) 3.29 (s, 3 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1261524-75-7, 3-Bromo-2-chlorobenzyl Alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; BELANGER, David B.; FLOHR, Stefanie; GELIN, Christine Fang; JENDZA, Keith; JI, Nan; LIU, Donglei; LORTHIOIS, Edwige Liliane Jeanne; KARKI, Rajeshri Ganesh; MAINOLFI, Nello; POWERS, James J.; RANDL, Stefan Andreas; ROGEL, Olivier; VULPETTI, Anna; YOON, Taeyoung; WO2015/9977; (2015); A1;,
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