Related Products of 230295-16-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 230295-16-6 as follows.
To a solution of 3-fluoro-4-(trifluoromethyl)benzyl alcohol (10 g, 52 mmol) in chloroform (20 ml) was added thionyl chloride (18.5 ml, 257 mmol) and the mixture was heated under reflux for 4 hrs. The reaction solution was concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1) to give 3-fluoro-4-(trifluoromethyl)benzyl chloride (9.52 g, 87%). IR nu maxKBrcm-1: 1634, 1589, 1512, 1435.1H-NMR (CDCl3) delta: 4.58 (2H, s), 7.20-7.32 (2H, m), 7.60 (1H, t, J = 7.6 Hz).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,230295-16-6, its application will become more common.
Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1362846; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts