In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. Quality Control of 1-(2,6-Dichloro-3-fluorophenyl)ethanol
To a solution of A5 (147.6g, 0.71mol) in THF (3L) was added 60% NaH (28.4g, 0.71mol) at 0C, the resulting mixture was stirred at that temperature for 30min, was then added A3 (147g, 0.71mmol) quickly. The resulting mixture was heated under reflux overnight and evaporated. The residue was purified by column chromatography (PE:EA=4:1) to provide the advanced intermediate A6 (89.3g, 37.6%).
The synthetic route of 756520-66-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; XCOVERY HOLDING COMPANY, LLC; LIANG, Congxin; WO2012/48259; (2012); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts