Reference of 1261524-75-7, Adding some certain compound to certain chemical reactions, such as: 1261524-75-7, name is 3-Bromo-2-chlorobenzyl Alcohol,molecular formula is C7H6BrClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1261524-75-7.
To (3-bromo-2-chlorophenyl)methanol (CAS 1261524-75-7) (0.253 g, 1.142 mmol) in DCM (1 1.4 mL) at 0 C was added TEA (0.398 mL, 2.86 mmol) followed by MsCI (0.134 mL, 1.713 mmol) and the ice bath was removed and the solution was allowed to stir at room temperature for 30 minutes. At this point, the reaction was placed in an ice bath and diluted with DCM and a saturated solution of sodium bicarbonate. This mixture was passed thorugh a phase separator to remove the water layer. The organics were dried and concentrated to obtain the title compound. 1H NMR (400 MHz, DMSO-c/6) delta ppm 7.85 (dd, J=8.07, 1.47 Hz, 1 H) 7.63 (dd, J=7.70, 1.47 Hz, 1 H) 7.37 (t, J=7.83 Hz, 1 H) 5.37 (s, 2 H) 3.29 (s, 3 H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1261524-75-7, 3-Bromo-2-chlorobenzyl Alcohol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; BELANGER, David B.; FLOHR, Stefanie; GELIN, Christine Fang; JENDZA, Keith; JI, Nan; LIU, Donglei; LORTHIOIS, Edwige Liliane Jeanne; KARKI, Rajeshri Ganesh; MAINOLFI, Nello; POWERS, James J.; RANDL, Stefan Andreas; ROGEL, Olivier; VULPETTI, Anna; YOON, Taeyoung; WO2015/9977; (2015); A1;,
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