In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, the common compound, a new synthetic route is introduced below. Recommanded Product: 2854-16-2
To a solution of 2-fluorobenzene-1-sulfonyl chloride (15 g, 77 mmol) in tetrahydrofuran (THF) (300 ml.) at 0C was added potassium carbonate (13.85 g, 100 mmol), water (110 ml.) and 1-amino-2-methylpropan-2-ol (6.87 g, 77 mmol) and was stirred for 4 h at 25 C. The reaction mixture was quenched with ice cold water (200 mL) and extracted with ethyl acetate (2 X 200ml_), washed with brine (100ml_) then concentrated to provide the title compound as a white solid. (17 g, 67.9 mmol, 88% yield). LCMS m/z 248.2 (M+H)+,1.678min (ret.time).
The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; COOPER, Anthony William James; GOODWIN, Nicole Cathleen; GRIFFITHS-JONES, Charlotte Mary; HEIGHTMAN, Thomas Daniel; KERNS, Jeffrey K.; WILLEMS, Hendrika Maria Gerarda; YAN, Hongxing; (215 pag.)WO2018/109649; (2018); A1;,
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