Electric Literature of 2568-33-4 , The common heterocyclic compound, 2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stirred solution of compound la (4 g, 38 mmol) in DMF (30 mL) was added NaH (3.3 g,8.4 mmol, 60% in mineral oil) at 0C over 10 mins. The mixture was stirred for half an hour atr.t., and then cooled to 0 C. Then compound 7-1 (6 g, 32 mmol) in DMF (20 mL) was added to5 the reaction, and the reaction was stirred at r.t. for 12 h. The reaction was poured into water(100 mL), and the resulting mixture was stirred for 10 min. The mixture was then was extractedwith EtOAc (60 mL x 3). The organic layers were combined, washed with water (60 mL), brine( 60 mL ), dried and concentrated to give crude product, which was used directly for the next stepwithout further purification. MS (ESI) m/z: 274.1.
The synthetic route of 2568-33-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; HAGMANN, William K.; NARGUND, Ravi P.; BLIZZARD, Timothy A.; JOSIEN, Hubert; BIJU, Purakkattle; PLUMMER, Christopher W.; DANG, Qun; LI, Bing; LIN, Linus S.; CUI, Mingxiang; HU, Bin; HAO, Jinlai; CHEN, Zhengxia; WO2014/19186; (2014); A1;,
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