Electric Literature of 35106-82-2 ,Some common heterocyclic compound, 35106-82-2, molecular formula is C9H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 1: 1-(chloromethyl)-2-vinylbenzene A solution of (2-vinylphenyl)methanol (3.10 g, 23.1 mmol) in DCM (30 mL) was cooled down to 0¡ã C., and then added MsCl (2.01 mL, 27.7 mmol) dropwise. The resulted mixture was stirred at room temperature for overnight. After the mixture was diluted with DCM (50 mL), the organic layer was washed with H2O (30 mL*2), saturated NaHCO3 aqueous solution and brine successively, then dried over sodium sulfate, filtered and concentrated to afford 1-(chloromethyl)-2-vinylbenzene (2.92 g, yield: 83percent) as colorless oil, which can directly used for next step.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 35106-82-2, (2-Vinylphenyl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SHANGHAI DE NOVO PHARMATECH CO. LTD.; GAO, Daxin; YANG, Heping; WANG, Pei; (84 pag.)US2017/37038; (2017); A1;,
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