Related Products of 627-30-5, Adding some certain compound to certain chemical reactions, such as: 627-30-5, name is 3-Chloropropan-1-ol,molecular formula is C3H7ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-30-5.
General procedure: A 250 mL round-bottom flask equipped with aTeflon-coated magnetic stirring bar, reflux condenser and drying tube wascharged with 3.46 g (20.0 mmol, 1.0 eq) 4-bromophenol (13). It was dissolved in 100 mLDMF and 5.54 g (40.0 mmol, 2.0 eq) K2CO3, 332 mg(2.00 mmol, 10 mol%) KI and 30.0 mmol (1.5 eq) of thedesired chloroalcohol were added, respectively. Afterwards the colorlesssuspension was heated in an oil bath to 120 C and vigorously stirred atthis temperature until reaction control viaTLC showed full conversion of the starting material (20 h to 40 h).The resulting brownish suspension was cooled to room temperature and thesolvent was carefully removed in the vacuum of an oil pump. Afterwards200 mL EtOAc were added to the brownish residue, the organic phase was washedwith H2O (2 x 100 mL), brine (1 x 100 mL), dried over MgSO4,filtered and concentrated on a rotary evaporator. Finally, the brownish, oilyresidue was purified via flash column chromatography (250 g SiO2,21.0 x 6.0 cm) and the colorless liquid dried under high vacuum
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 627-30-5, 3-Chloropropan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Leypold, Mario; Wallace, Paal W.; Kljajic, Marko; Schittmayer, Matthias; Pletz, Jakob; Illaszewicz-Trattner, Carina; Guebitz, Georg M.; Birner-Gruenberger, Ruth; Breinbauer, Rolf; Tetrahedron Letters; vol. 56; 41; (2015); p. 5619 – 5622;,
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