Adding a certain compound to certain chemical reactions, such as: 26021-57-8, 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol
Compound 54 (50 mg, 0.33 mmol) was dissolved in a solution of /-PrOH/H20 (9/1 , 3 mL) at 80 C for 30 min. Compound 57 (99 mg, 0.33 mmol) was added to the solution above in 5 portions over 15 mins. Then the reaction mixture was treated with HCIO4 (70%, 30 m). The resulting solution was stirred overnight. After which, the dark blue solution was evaporated under reduced pressure, and the residue was purified on a Biotage Isolera Flash System using SNAP Ultra cartridge with a mobile phase of CHCI3 and MeOH containing 0.5% formic acid (gradient, 2-15% of MeOH in CHCI3). The fractions containing product were pooled and evaporated, affording LGW-03-65 (62 mg, 55%) as a dark blue solid.
The synthetic route of 26021-57-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; OREGON HEALTH & SCIENCE UNIVERSITY; OREGON STATE UNIVERSITY; GIBBS, Summer L.; BARTH, Connor W.; ALANI, Wathah G.; SHAH, Vidhiben; WANG, Lei; (167 pag.)WO2020/33435; (2020); A1;,
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