Adding a certain compound to certain chemical reactions, such as: 623-50-7, Ethyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks
Intermediate 50b: Ethyl 2-(prop-2-yn-1-yloxy)acetate Ethyl 2-hydroxyacetate (9.3 mL, 96.1 mmol) was added to a 200-mL round-bottomed flask in THF (100 mL). To the solution was added 60% sodium hydride 60% in mineral oil (4.61 g, 115 mmol) slowly over 5 mins. The suspension was stirred at RT for 1 hour before 3-bromoprop-1-yne (10.7 mL, 96.1 mmol) was added. The reaction mixture was stirred at RT over the weekend. The mixture was concentrated under reduced pressure. To the residue was added diethyl ether (30 mL) and water (50 mL). After partition, the organic phase was washed with water (2*50 mL). The organic layer was dried (Na2SO4) and concentrated to give the crude product. The crude product was added to a silica gel column (80 g) and was eluted with EtOAc/hexane (0-25%). Collected fractions were concentrated to give the title compound (7.0 g, 51%). 1H NMR (DMSO-d6) 1.21 (3H, t), 3.49 (1H, s), 4.08-4.18 (4H, m), 4.23 (2H, d).
The synthetic route of 623-50-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AstraZeneca AB; YANG, Bin; KETTLE, Jason Grant; HAYHOW, Thomas George Christopher; RASMUSSON, Timothy Gordon; NISSINK, Johannes Wilhelmus Maria; FALLAN, Charlene; Lamont, Gillian McGregor; (308 pag.)US2019/194190; (2019); A1;,
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