Synthetic Route of 826-45-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 826-45-9, name is Bicyclo[2.2.2]octane-1,4-diyldimethanol. This compound has unique chemical properties. The synthetic route is as follows.
A solution of 13 (1.00 g, 5.8737 mmol) in 5 ml of DMF was added dropwise to a suspension of NaH (352.4 mg, 8.81 mmol) in 5ml of DMF at 0¡ãC under Ar atmosphere, and the reaction mixture was stirred at room temperature for 1 h. A solution of 14 (2.0464 g, 5.874 mmol) in 5ml of DMF was added to the reaction mixture at 0¡ãC, and the mixture was stirred at room temperature overnight. DMF was removed under reduced pressure, and the residue was quenched with 3 ml of cold water, extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2SO4, and concentrated. The residue was purified by silica gel column chromatography (ethyl acetate : n-hexane 1 : 4) to give 16 (471.7 mg, 23percent) as colorless oil. 1H-NMR (400 MHz, CDCl3) 1.46-1.39 (m, 12 H), 1.60 (dd, J = 1.37, 13.28 Hz, 1 H) 1.86 (dq, J = 5.38, 13.28 Hz,1 H), 3.17-3.11 (m, 2 H), 3.27 (s, 2 H), 3.45-3.42 (m, 1 H), 3.61-3.58 (m, 1 H), 4.15-3.95 (m, 2 H), 4.31-4.23 (m, 1 H), 5.51 (s, 1 H), 7.38-7.32 (m, 3 H), 7.49 (d, J= 8.3 Hz, 2 H).
According to the analysis of related databases, 826-45-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Wongmayura, Angsuma; Fujii, Shinya; Ito, Shigeru; Kano, Atsushi; Taoda, Yoshiyuki; Kawachi, Emiko; Kagechika, Hiroyuki; Tanatani, Aya; Bioorganic and Medicinal Chemistry Letters; vol. 22; 4; (2012); p. 1756 – 1760;,
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