Adding a certain compound to certain chemical reactions, such as: 873-76-7, (4-Chlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (4-Chlorophenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (4-Chlorophenyl)methanol
General procedure: 0.5 mmol substrate, 1.5 mmol NH4OAc, 0.15 mmol TEMPO, 2 mL AcOH and 0.15 mmol HNO3 weresuccessively added to a dried 45 mL tube filled with 1atm oxygen. Then the reaction tube was sealed andplaced in a constant-temperature oil bath to perform the reaction for 12 h. Once the reaction time wasreached, the mixture was cooled to room temperature. Then the mixture was alkalized to pH 7-8 with sodiumhydroxide aqueous solution. GC analysis of organic phase provided the GC yields of the products.Subsequently, the crude product from another parallel experiment was purified by column chromatography,and identified by 1H-NMR, 1C-NMR or GC-MS
The synthetic route of 873-76-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhao, Bo; Ren, Yun-Lai; Ren, Fangping; Tian, Xinzhe; Zhao, Shuang; Letters in Organic Chemistry; vol. 15; 7; (2018); p. 627 – 632;,
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