Electric Literature of 46190-45-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.46190-45-8, name is Methyl 4-(2-hydroxyethyl)benzoate, molecular formula is C10H12O3, molecular weight is 180.2005, as common compound, the synthetic route is as follows.
A solution of 13 (1.16 g, 6.44 mmol) in CH2Cl2 (20 mL) was added DAST (1.56 g, 9.66 mmol) at 0 C. The mixture was warmed to ambient temperature and stirred overnight, then ethyl acetate(100 mL) was added, washed with water (50 mL), saturated Na2CO3 (50 mL), saturated NaCl (50 mL), and dried over Na2SO4.After evaporation of the solvent in vacuo, the crude product was purified by chromatography with hexane-ether (10:1) to afford 1.06 g (91%) of 15 as a colorless oil. TLC Rf 0.25 (hexane-ether10:1); 1H NMR (300 MHz, CDCl3) delta 8.01 (d, J = 8.4 Hz, 2H), 7.33(d, J = 8.1 Hz, 2H), 4.67 (dt, J = 47.1 Hz, J = 6.3 Hz, 2H), 3.93 (s,3H), 3.08 (dt, J = 24.6 Hz, J = 6.3 Hz, 2H).
The chemical industry reduces the impact on the environment during synthesis 46190-45-8, I believe this compound will play a more active role in future production and life.
Reference:
Article; Li, Aixiao; Mishra, Yogesh; Malik, Maninder; Wang, Qi; Li, Shihong; Taylor, Michelle; Reichert, David E.; Luedtke, Robert R.; MacH, Robert H.; Bioorganic and Medicinal Chemistry; vol. 21; 11; (2013); p. 2988 – 2998;,
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