Electric Literature of 41175-50-2 ,Some common heterocyclic compound, 41175-50-2, molecular formula is C12H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
/V-ethyl-/V-(2,3,6,7-tetrahydro-1 H,5H,12H-quinolizino[1,9-bc]phenoxazin-12- ylidene)ethanaminium (LGW-02-86). Compound 26 (50 mg, 0.26 mmol) was dissolved in a solution of /-PrOH/H20 (9/1 , 1 mL) at 80 C for 30 min. A suspended solution of 35 (58 mg, 0.28 mmol) and HCICU (70%, 30 mI_) in 90% /-PrOH (2 ml_) was added in 4 portions over 1 h. The resulting solution was stirred overnight. After which, the dark blue solution was evaporated under reduced pressure, and the residue was purified on a Biotage Isolera Flash System using SNAP Ultra cartridge with a mobile phase of CHCI3 and MeOH containing 0.5% formic acid (gradient, 2-15% of MeOH in CHCI3). The fractions containing product were pooled and evaporated, affording LGW-02-86 (36 mg, 34%) as a dark blue solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,41175-50-2, its application will become more common.
Reference:
Patent; OREGON HEALTH & SCIENCE UNIVERSITY; OREGON STATE UNIVERSITY; GIBBS, Summer L.; BARTH, Connor W.; ALANI, Wathah G.; SHAH, Vidhiben; WANG, Lei; (167 pag.)WO2020/33435; (2020); A1;,
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