Adding a certain compound to certain chemical reactions, such as: 748805-85-8, (2-Amino-5-fluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 748805-85-8, blongs to alcohols-buliding-blocks compound. Recommanded Product: 748805-85-8
To a Schlenk tube were added (2-aminophenyl)methanols 1 (0.2 mmol), aldehydes 2 (0.3 mmol), CAN (0.3 mmol), CuCl (0.02 mmol), 2,2′-bipyridine (0.02 mmol), TEMPO (0.02 mmol), CsOH(0.5 mmol), and CH3CN (2 mL). Next the tube was charged with O2 (1 atm), and was stirred constantly at 30 C for 24 h, then at 60 C for 24 h. After the completion of the reaction, the reaction mixture was cooled to room temperature, diluted with ethyl acetate, and washed with brine. After the aqueous layer was extracted with ethyl acetate, the combined organic layers were dried over anhydrous MgSO4 and evaporated under reduced pressure. The residue was purified by flash column chromatography (hexane/ethyl acetate) to afford the desired products 3.
The synthetic route of 748805-85-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ye, Leping; Yu, Lin; Zhu, Lijun; Xia, Xiaodong; Molecules; vol. 18; 11; (2013); p. 13860 – 13869;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts