Application of 395-23-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 395-23-3, name is Phenyl(4-(trifluoromethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.
A mixture of methyl 2-hydroxy-5-nitrobenzoate (1.93 g, 9.81 mmol), (4-trifluoromethylphenyl)(phenyl)methanol (3.00 g, 11.8 mmol), 40% solution of diethyl azodicarbonate in toluene (6.83 g, 15.7 mmol) and a solution (8 ML) of triphenylphosphine (3.09 g, 11.8 mmol) in DMF was stirred at room temperature for 12 hours, and the reaction solution was poured into ice-water and was extracted with ethyl acetate.. The extracted solution was washed with water, was dried with anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure.. The residue was purified by silicagel column chromatography (hexane:ethyl acetate = 20:1), to obtain the titled compound as oil. 3.37 g (79.7%) 1H-NMR (CDCl3) delta; 4.00 (3H, s), 6.46 (1H, s), 7.00 (1H, d, J = 9.2 Hz), 7.26 to 7.72 (9H, m), 8.20 (1 H, dd, J = 3.0, 9.2 Hz), 8.74 (1H, d, J = 3.0 Hz)
According to the analysis of related databases, 395-23-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1437344; (2004); A1;,
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