Adding a certain compound to certain chemical reactions, such as: 2077-19-2, 2-(4-Bromophenyl)propan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-(4-Bromophenyl)propan-2-ol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 2-(4-Bromophenyl)propan-2-ol
To a 50 mL round-bottom flask were placed 2-(4-bromophenyl) propan-2-ol (5.10 g, 23.71 mmol), 2H-l ,2,3-triazole (3.28 g, 47.4 mmol), acetonitrile (10 mL) and iron (III) trichloride (1.50 g, 9.48 mmol). The reaction mixture was heated at 60C for 16 hours and then quenched by a saturated aqueous ammonium chloride solution (50 mL). The mixture was extracted with ethyl acetate (3 x 80 mL) and the combined organic layers dried over sodium sulfate and filtered. The filtrate was concentrated under vacuum to afford 3.50 g of the crude product mixture as a yellow oil that was then purified by prep-HPLC (ccolumn: X Bridge CI 8, 19 x 150 mm, 5 um; mobile phase A: water/0.05% trifluoroacetic acid, mobile phase B: acetonitrile; flow rate: 20 mL/min; gradient: 30%B to 70%B in 10 min; 220 nm) to give the title compounds: l-(2-(4-Bromophenyl)propan-2-yl)-lH-l ,2,3-triazole, LCMS (ESI) calc’d for CiiHi3BrN3 [M + H]+: 266, 268 (1 : 1), found 266, 268 (1 : 1); 1H NMR (400 MHz, CDC13) delta 7.68 (s, 2H), 7.43 (d, / = 8.8 Hz, 2H), 6.93 (d, / = 8.8 Hz, 2H), 2.10 (s, 6H); 2-(2-(4- Bromophenyl)propan-2-yl)-2H-l ,2,3-triazole, LCMS (ESI) calc’d for CnHi3BrN3 [M + H]+: 266, 268 (1 : 1), found 266, 268 (1 : 1); 1H NMR (400 MHz, DMSO-d6) delta 8.28 (s, 1H), 7.82 (s, 1H),7.54 (d, / = 8.4 Hz, 2H), 6.93 (d, / = 8.4 Hz, 2H), 2.02 (s, 6H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2077-19-2, 2-(4-Bromophenyl)propan-2-ol, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DINSMORE, Christopher; FULLER, Peter; GUERIN, David; KATZ, Jason David; THOMPSON, Christopher F.; FALCONE, Danielle; DENG, Wei; TORRES, Luis; ZENG, Hongbo; BAI, Yunfeng; FU, Jianmin; KONG, Norman; LIU, Yumei; ZHENG, Zhixiang; WO2014/146493; (2014); A1;,
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