Adding a certain compound to certain chemical reactions, such as: 616-29-5, 1,3-Diaminopropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1,3-Diaminopropan-2-ol, blongs to alcohols-buliding-blocks compound. Safety of 1,3-Diaminopropan-2-ol
General Procedure for the Synthesis of the BOC-Protected Amino Alcohols 35a-eA solution of the appropriate amino alcohol (6.0 mmol), di-tert-butyl dicarbonate (1.96 g, 9.0 mmol) and NaHCO3 (2.5 g, 30.0 mmol) in 10 ml of dioxane and 10 ml H2O was stirred overnight at room temperature. Ethyl acetate (50 ml) was then added and the organic phase was washed with saturated NaHCO3 (2¡Á50 ml), 10% HCl (2¡Á50 ml), and brine (50 ml). The organic phase was then dried with MgSO4, filtered and evaporated. The product was purified as indicated.Di-tert-butyl 2-hydroxypropane-1,3-diyldicarbamate 35aThe title compound 35a was prepared in 35% yield (610 mg) using the general procedure and employing 3.92 g of di-tert-butyl dicarbonate instead of the indicated amount and the product was obtained as white solid after recrystalized from hexanes.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,616-29-5, 1,3-Diaminopropan-2-ol, and friends who are interested can also refer to it.
Reference:
Patent; METHYLGENE INC.; US2008/132525; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts