Adding a certain compound to certain chemical reactions, such as: 96-35-5, Methyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Methyl 2-hydroxyacetate, blongs to alcohols-buliding-blocks compound. Safety of Methyl 2-hydroxyacetate
To 17.09 g of Compound (5) shown below (methyl glycolate, manufactured by TCI), 30,00 g of tetrahydrofuran (THF) was added, and 21.15 g of triethylamine was further added. The mixture was cooled to 0C, and 20.85 g of methacrylic acid chloride was then added dropwise. After returning the temperature to room temperature, the mixture was stirred for 2 hours. A sodium hydrogencarbonate aqueous solution was added, followed by extraction with ethyl acetate. Organic layers were gathered, to which was then added MgSO4, and the resulting mixture was filtered and concentrated to obtain 28.51 g of Compound (6) (yield: 95 %). 1H-NMR, (400 MHz in (CD3)2CO): ? (ppm) = 1.94 to 2.04 (3H), 3.71 to 3.72 (3H), 4.73 (2H), 5.72 (1H), 6.15 (1H)
The synthetic route of 96-35-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fujifilm Corporation; EP2196462; (2010); A1;,
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