With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56456-47-4, name is 2,4-Difluorobenzyl Alcohol, molecular formula is C7H6F2O, molecular weight is 144.12, as common compound, the synthetic route is as follows.HPLC of Formula: C7H6F2O
EXAMPLE 4 4-Cyano-6-(2,4-difluorobenzyloxy)-2-(1 -methyl-3-trifluoromethylpyrazol-5-yloxy)pyridine Sodium hydride (0.1 g, 60%, 2.5 mmol) is added to a solution of 2,4-difluorobenzyl alcohol (0.28 ml, 2.5 mmol) in sulfolane (5 ml) at 50 C. After 1 hour at 50 C., 4-cyano-2,6-bis(1-methyl-3-trifluoromethylpyrazol-5-yloxy)pyridine (1 g, 2.3 mmol) (from Example 2) is added to the reaction mixture. The mixture is heated to 90 C. overnight. After cooling, the reaction mixture is diluted with pentane/ethyl acetate (by volume ration 1/1) and filtered through a bed of silica gel. The filtrate is washed 6 times with water. The organic layer is dried with anhydrous magnesium sulfate, filtered and evaporated in vacuo. Purification by flash chromatography (silica gel: pentane/ethyl acetate 8/2 v/v) and washing of the product with diisopropyl ether yields the title compound (0.2 g, 21% yield) of melting point 109 C.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,56456-47-4, 2,4-Difluorobenzyl Alcohol, and friends who are interested can also refer to it.
Reference:
Patent; American Cyanamid Company; US5922738; (1999); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts