Related Products of 931-17-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 931-17-9, name is 1,2-Cyclohexanediol. A new synthetic method of this compound is introduced below.
(Example 7a) Cyclopent-1-ene-1-carbaldehyde A mixture of sodium periodate (28.6 g, 134 mmol) and water (250 ml) was added to a mixture of 1,2-cyclohexanediol (12 g, 103 mmol) and diethyl ether (150 ml), which was stirred at room temperature for 35 minutes. A 20% aqueous potassium hydroxide solution (40 ml, 206 mmol) was added to the reaction mixture, which was stirred at room temperature for two hours. The reaction mixture was extracted with diethyl ether twice. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off to give the title compound (6.1 g, yield 61.6%). 1H-NMR (400 MHz, CDCl3) delta ppm; 1.96-2.04 (2H, m), 2.50-2.57 (2H, m), 2.58-2.66 (2H, m), 6.87-6.90 (1H, m), 9.80 (1H, s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,931-17-9, 1,2-Cyclohexanediol, and friends who are interested can also refer to it.
Reference:
Patent; Eisai R&D Management Co., Ltd.; YOSHIDA Ichiro; OKABE Tadashi; MATSUMOTO Yasunobu; WATANABE Nobuhisa; OHASHI Yoshiaki; ONIZAWA Yuji; HARADA Hitoshi; EP2757103; (2014); A1;,
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