Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 217479-60-2, name is 2,4,6-Trichlorobenzyl alcohol. A new synthetic method of this compound is introduced below., name: 2,4,6-Trichlorobenzyl alcohol
PREPARATION EXAMPLE 4: N-rri -(2.4.6-trichlorophenvncvclopropyllmethvn-3- (trifluoromethyl)pyridine-2-carboxamide (Compound A29)Step 1 : 1 ,3,5-trichloro-2-(chloromethyl)benzeneTo a stirred solution of (2,4,6-trichlorophenyl)methanol (2g, 9.4574 mmol) in chloroform (20 mL) kept under N2 atmosphere, thionyl chloride (1 .25 ml_, 17.023 mmol), was added slowly at 0C over a period of 10 min followed by a catalytic amount of DMF (35 mg, 0.4733 mmol). The reaction mixture was allowed to stirred at RT for 2h.The reaction mixture was quenched with 10 mL of water; the aqueous layer is extracted with dichloromethane (3 times). The combined organic layer were washed with 5% Na2C03 solution (2*10 mL), followed by NaCI (10mL) and dried over Na2S04. The solvent was evaporated under reduced pressure to give an yellow oil (1.78 gr). The oil was diluted in EtOAc and washed twice with NaCI (3 mL), then dried over NaS04, filtrated and evaporated to give 1.58 g of desired product.1H-NMR (CDCI3): 7.4 (s, 2H); 4.8 (s, 2H).
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Reference:
Patent; SYNGENTA PARTICIPATIONS AG; LOISELEUR, Olivier; PITTERNA, Thomas; O’SULLIVAN, Anthony, Cornelius; LUKSCH, Torsten; KICKOVA, Anna; WO2013/64520; (2013); A1;,
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