Reference of 769-30-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol. A new synthetic method of this compound is introduced below.
A solution of (benzo[d][l,3]dioxol-7-yl)methanol (2 g, 13.14 mmol) and di(lNo.-imidazol-l-yl)methanone (4.26 g, 26.28 mmol) in 20 mL CH2CI2 was heated overnight at 50 C. The reaction was quenched with water, extracted with CH2CI2, dried over Na2S04, filtered, and concentrated. Purification via silica gel chromatography using 10-70% EtOAc in CH2CI2 gave (benzo[d][l,3]dioxol-7-yl)methyl 177-imidazole-l-carboxylate (2.8 g, 86%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,769-30-2, Benzo[d][1,3]dioxol-4-ylmethanol, and friends who are interested can also refer to it.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2006/28904; (2006); A1;,
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