Adding a certain compound to certain chemical reactions, such as: 13401-56-4, 3-Chloro-2,2-dimethylpropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13401-56-4, blongs to alcohols-buliding-blocks compound. Safety of 3-Chloro-2,2-dimethylpropan-1-ol
Example 6 :1-chloro-2,2-dimethyl-3,3-diethoxy–propane (formula (IV): X=Cl, R1= R2= CH3CH2- (IVC)) ;A solution of 6.76 ml (77.5mmol) de (COCl)2 in 220 ml of dry dichloromethane is cooled to -40C. Then 153.8 ml (10.9 mmol) of dimethylsulfoxide are added slowly. 5 minutes later, a solution of 7.5 g of 1-chloro-2,2-dimethyl-propanol (formula (VIC): X=Cl) in 61 ml of dichloromethane is added. The mixture is stirred for 15 minutes followed by the addition of 36 ml (264.3mmol) de Et3N. 30ml of dichloromethane are added and the mixture is warmed to room temperature. The organic phase is washed with water (3×150 ml), dried over sodium sulfate, concentrated in vacuo (17C / 75 mbar). The oil obtained is solubilized in ethanol and the solution is heated under reflux with a catalytic amount of PTSA for 120 minutes, concentrated in vacuo (19C/32 mbar). After distillation at 62-65C under 10 mbar, 8 g of compound (IVC) are obtained (yield : 68%). H1RMN delta ppm : 0.96 (s,6H, 2CH3); 1.25 (t, 6H,J=8HZ; OCH2CH3); 3.44(s,2H,CH2Cl); 3.48-3.57 (m,2H,CH2O); 3.75-3.88 (m,2H, CH2O); 4.25 (s,1H,anomeric) 13C RMN delta ppm :15.4 (2C,CH3); 20.4 (2C, OCH2CH3); 41.4 (q);53.1 (CH2Cl);65.8 ((2C, OCH2CH3); 107.7 (anomeric). IR(film) cm-1: 656; 1063; 1249; 1381;1474; MS m:z =159
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13401-56-4, its application will become more common.
Reference:
Patent; Merck Sante; EP1591434; (2005); A1;,
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