In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68120-35-4, name is (3-Bromo-4-methylphenyl)methanol, the common compound, a new synthetic route is introduced below. Quality Control of (3-Bromo-4-methylphenyl)methanol
To a stirred solution of (3-bromo-4-methylphenyl) methanol (5.5 g, 27.4 mmol) in THF (50 mL) at -78C, n-BuLi [(18.6 g, 2.5 eq (2.5M soln) was added and the solution was stirred at same temperature for 30 mm. Then, 002 gas was purged (generated from dry ice) for about 10 mm. The reaction mixture was quenched with ammonium5 chloride and acidified with 1 N HCI, extracted with ethyl acetate, the organic layer was washed with water, brine solution. Then, it was dried over anhydrous Na2S04 and concentrated under reduced pressure and washed with n-hexane to obtain the title compound (4.0 g, 87.85%) as an off white solid. LCMS : 165.0 (M-H) 1H NMR:(CDCI3, 300MHz) 6 12.67 (5, 1H), 7.79 (5, 1H), 7.36-7.38 (d, 1H), 7.23-7.25 (d, 1H), 10 5.23 (5, 1H), 4.49 (5, 2H), 2.50 (5, 3H).
The synthetic route of 68120-35-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; MADANAHALLI RANGANATH RAO, Jagannath; GURRAM RANGA, Madhavan; PACHIYAPPAN, Shanmugam; WO2014/202528; (2014); A1;,
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