Reference of 61367-62-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.61367-62-2, name is 4-Bromo-3,5-dimethoxybenzyl alcohol, molecular formula is C9H11BrO3, molecular weight is 247.09, as common compound, the synthetic route is as follows.
Synthesis of 2-bromo-5-[(1-isopropoxyethoxy)methyl]-1,3-dimethoxybenzene Cyclopentyl methyl ether (100 mL), tetrahydrofuran (10 mL), isopropyl vinyl ether (9.3 mL), and pyridinium p-toluenesulfonate (1.00 g) were sequentially added to (4-bromo-3,5-dimethoxyphenyl)methanol (10.02 g), and the mixture was stirred for about 2.5 hours at room temperature. The reaction liquid was filtered, and the filtrate was washed sequentially with a 5percent aqueous solution of sodium hydrogen carbonate and water. The solvent was distilled off under reduced pressure, and the residue was azeotropically boiled with cyclopentyl methyl ether, to obtain 15.75 g (content 13.47 g, yield 99.6percent) of the title compound as a pale orange oily matter. 1H-NMR (400MHz, CDCl3) delta: 1.18 (d, J=6.4Hz, 3H), 1.23 (d, J=6.0Hz, 3H), 1.38 (d, J= 5.2Hz, 3H), 3.88-3.94 (m, 1H), 3.90 (s, 6H), 4.49 (d, J=12.0Hz, 1H), 4.61 (d, J=12.4Hz, 1H), 4.87 (q, J=5.2Hz, 1H), 6.58 (s, 2H).
The chemical industry reduces the impact on the environment during synthesis 61367-62-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2202233; (2010); A1;,
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