Electric Literature of 346-06-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.
Reference Production Example 3; Into 6 ml of N,N-dimethylformamide was suspended 0.16 g of sodium hydride (60percent oily), and 0.61 g of 2-trifluoromethylbenzyl alcohol was added under water cooling, and the resultant mixture was stirred for 15 minutes. Thereafter, to the mixture was added 0.4 g of 2-cyano-4-chloropyridine, and the mixture was stirred for 2 hours. The resultant reaction mixture was poured into a saturated ammonium chloride aqueous solution, and the mixture was extracted with t-butyl methyl ether three times. The organic layers obtained by extraction were combined and washed with saturated saline, dried over anhydrous magnesium sulfate, then, concentrated. The resultant residue was subjected to silica gel column chromatography to obtain 0.55 g of 4-(2-trifluoromethylbenzyloxy)pyridine-2-carbonitrile. [Show Image] 1H-NMR:5.34(s,2H),7.05(d, 1H),7.28(s, 1H), 7.50(brs, 1H), 7.62(br s,2H), 7.75(d, 1H), 8.53(d, 1H)
Statistics shows that 346-06-5 is playing an increasingly important role. we look forward to future research findings about (2-(Trifluoromethyl)phenyl)methanol.
Reference:
Patent; Sumitomo Chemical Company, Limited; EP2332936; (2011); A1;,
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