Electric Literature of 179811-63-3 ,Some common heterocyclic compound, 179811-63-3, molecular formula is C8H10ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound VI (9.63 g, 25.0 mmol), 2-amino-2-(3-chlorophenyl)ethyl-1-ol (VII-2) (4.29 g, 25.0 mmol) and triethylamine (10.4 mL, 74.9mmol) dissolved in methanol (100mL), reflux reaction for about 6h, until TLC (dichloromethane: methanol = 20:1) detection of the reaction of the raw materials was completed, cooled to below 10 C in an ice bath, stirred for 30min, solid precipitation, suction filtration ,A white solid 7.2 g was obtained, yield: 64.9%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 179811-63-3, 2-Amino-2-(3-chlorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; China Pharmaceutical University; Xu Yungen; Ji Dezhong; Zhang Lingzhi; Zhu Qihua; Bai Ying; Wu Yaoyao; (41 pag.)CN109608444; (2019); A;,
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