Related Products of 22348-44-3, Adding some certain compound to certain chemical reactions, such as: 22348-44-3, name is trans-4-(Methylamino)cyclohexanol,molecular formula is C7H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22348-44-3.
630 mg of sodium hydride (95%) were suspended in 40 mL of dimethyl acetamide. 1.45 g of 4-methylamino-cyclohexanol (150), dissolved in 40 mL of dimethyl acetamide, were added dropwise and 15 min. later 2.48 g of 6-fluoro-2-(4-methoxy- benzyl)-2H-isoquinolin-1-one (177), dissolved in another 40 mL of dimethyl acetamide, were added. The reaction mixture was stirred at 80 0C until the reaction was complete. The mixture was poured into an ice-water mixture, extracted three times with methyl- tert.-butyl ether and the combined organic layer was dried over sodium sulfate and evaporated. Water was added and the crude product was subjected to lyophilization to remove remainders of dimethyl acetamide.The obtained product is sufficiently pure for further conversion. Rt = 1.24 min (Method B), detected mass: 393.2 (M+H+).
According to the analysis of related databases, 22348-44-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SANOFI-AVENTIS DEUTSCHLAND GMBH; WO2007/12422; (2007); A1;,
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