Adding a certain compound to certain chemical reactions, such as: 6850-39-1, 3-Aminocyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 3-Aminocyclohexanol, blongs to alcohols-buliding-blocks compound. name: 3-Aminocyclohexanol
To a solution of 4-chloropyrrolo[l,2-b]pyridazine-3-carbonitrile (15g) (0.15 g, 0.84 mmol) in DMF (2.5 mL) was added at room temperature 3-aminocyclohexanol (5In) (194 mgs, 1.68 mmol), DIPEA (0.87 mL, 5 mmol) and stirred at room temperature overnight. The reaction was quenched with water (10 mL) and extracted with ethyl acetate (10 mL). The aqueous layer was separated and extracted with ethyl acetate (2 x 10 mL). The organic layers were combined washed with water (2 x 10 ml), brine (10 mL), dried, filtered and concentrated in vacuum. The residue obtained was purified by flash column chromatography (silica gel 12g, eluting with 0- 100% ethyl acetate in hexanes) to furnish 4-(3-hydroxycyclohexylamino)pyrrolo[l,2- b]pyridazine-3-carbonitrile (51o) (0.105 g, 46 %) as a white solid: 1H NMR (300 MHz, DMSO) delta 7.90 (s, IH), 7.78 (d, J= 8.5 Hz, IH), 7.69 (dd, J= 2.6, 1.6 Hz, IH), 7.12 (dd, J= 4.4, 1.6 Hz, IH), 6.68 (dd, J= 4.4, 2.7 Hz, IH), 4.88 (d, J= 4.3 Hz, IH), 4.25 (m, IH), 3.54 (m, IH), 2.17 (m, IH), 1.92 (m,lH), 1.76 (d, J= 13.3 Hz, 2H), 1.54 – 1.24 (m, 3H), 1.16 (dd, J= 14.6, 10.6 Hz, IH). MS (ES+) 536.3 (2M+Na), MS (ES-) 291.0 (M+Cl).
The synthetic route of 6850-39-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda S.; KOTIAN, Pravin L.; KUMAR, V. Satish; WU, Minwan; LIN, Tsu-Hsing; WO2011/14817; (2011); A1;,
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