Reference of 1611-56-9 , The common heterocyclic compound, 1611-56-9, name is 11-Bromoundecan-1-ol, molecular formula is C11H23BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
3,4-Dihydro-2H-pyran (21.87 g, 260 mmol) was added dropwise to a solution of 11-bromoundecanol (50.24 g, 200 mmol) and toluene-4-sulphonic acid monohydrate (80 mg, 0.4 mmol) in dichloromethane (100 ml). The reaction mixture was stirred at room temperature. After 24 h, the brown solution was filtered over a thin layer of silica gel. The filtrate was concentrated on the rotary evaporator and dried under fine vacuum. 65.85 g (196 mmol, 98% yield) of a light yellowish oil was obtained. 1H-NMR (CDCl3, 400 MHz): delta=1.23-1.37 (m, 12H), 1.37-1.47 (m, 2H), 1.48-1.64 (m, 6H), 1.65-1.76 (m, 1H), 1.77-1.90 (m, 3H), 3.35-3.42 (m, 3H), 3.46-3.53 (m, 1H), 3.70-3.75 (m, 1H), 3.84-3.90 (m, 1H), 4.56-4.58 (m, 1H). 13C-NMR (CDCl3, 100.6 MHz): delta=19.7, 25.4, 26.2, 28.2, 28.8, 29.4, 29.5, 29.6, 29.8, 30.8, 32.9, 33.9, 62.3, 67.7, 98.8.
The synthetic route of 1611-56-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IVOCLAR VIVADENT AG; Moszner, Norbert; Lamparth, Iris; Bock, Thorsten; Fischer, Urs Karl; Salz, Ulrich; Rheinberger, Volker; Liska, Robert; US2014/329929; (2014); A1;,
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