Adding a certain compound to certain chemical reactions, such as: 14320-38-8, Cyclopent-3-enol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 14320-38-8, blongs to alcohols-buliding-blocks compound. Product Details of 14320-38-8
Step (i): l-[(cyclopent-3-en-l-yloxy)methyl]-4-methoxybenzene To a solution of cyclopent-3-en-l-ol (CAS number 14320-38-8; 15 g, 178 mmol) in dry THF (357 ml) at 0 C under nitrogen was added sodium hydride (60%, 9.27 g, 232 mmol). After fizzing had ceased, to this was then added dropwise l-(chloromethyl)-4- methoxybenzene (CAS number 824-94-2; 31.4 ml, 232 mmol). The reaction was then allowed to warm to room temperature for 17 hours. The reaction mixture was quenched by the addition of methanol and then concentrated in vacuo. The organics were partitioned between ethyl acetate and water. The organics were dried over magnesium sulfate, concentrated in vacuo and purified by column chromatography (silica, 0-50%dichloromethane / petrol) to afford the title compound.1H NMR (400 MHz, OCM-d2) delta ppm 2.33 – 2.47 (m, 2 H), 2.49 – 2.66 (m, 2 H), 3.79 (s, 3 H), 4.20 – 4.32 (m, 1 H), 4.40 (s, 2 H), 5.62 – 5.75 (m, 2 H), 6.86 (d, 7=8.59 Hz, 2 H), 7.24 (d, 7=8.59 Hz, 2 H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14320-38-8, its application will become more common.
Reference:
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
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