With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19064-18-7, name is (2,6-Difluorophenyl)methanol, molecular formula is C7H6F2O, molecular weight is 144.12, as common compound, the synthetic route is as follows.Product Details of 19064-18-7
A solution of 2 ml (18.0 mmol) (2,6-difluorophenyl) methanol in 15 ml at 0 C stirred dry tetrahydrofuran was treated with 865.9 mg (6.21 mmol) of sodium hydride (60% in mineral oil), followed by 1.72 ml (18.0 mmol) of 2-bromopyridine.The solution was stirred at room erature for 15 hours.The reaction mixture was diluted (15 ml) with water and extracted with dichloromethane (2 x 20 ml).The organic phase was separated, dried with a phase separation cartridge, and concentrated in vacuo.The residue was purified by flash chromatography using a prepacked silica gel cartridge purified, yielding 800 mg of the target compound (eluent: 1 cyclohexane-ethyl acetate 10: 1 to 1) (15% of theory, 77%. purity).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,19064-18-7, (2,6-Difluorophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAF; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; BUCHGRABER, Philipp; HARTUNG, Ingo; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; MARQUARDT, TOBIAS; REDLICH, Gorden; DIETZ, Lisa; LI, Volkhart Min-Jian; (391 pag.)TW2016/5850; (2016); A;,
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