Related Products of 6642-34-8 , The common heterocyclic compound, 6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol, molecular formula is C8H7BrO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: In an oven dried round bottomed flask fitted with a rubber septum, were added alcohol 1 (100 mg, 0.31-0.53 mmol), alkyl acrylate (methyl, ethyl and tertiary butyl acrylate, or acrylo-nitrile) (1.55-2.67 mmol) and Cs2CO3 (0.62-1.07 mmol) followed by addition of toluene (2 mL) at room temperature under a nitrogen atmosphere. The stirred reaction mixture was heated in an oil bath at 50 C for 48 h. Progress of the Michael addition was monitored by TLC till the reaction is completed.GP-2 was followed to the alcohol 1f (100 mg, 0.43 mmol) with acrylonitrile (115 mg, 2.16 mmol) and Cs2CO3 (282 mg, 0.86 mmol) in toluene (2 mL) at room temperature under a nitrogen atmosphere. Then, the reaction mixture was heated in an oil bath at 50 C for 48 h.
The synthetic route of 6642-34-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Gopi Krishna Reddy; Krishna; Satyanarayana; Tetrahedron Letters; vol. 53; 42; (2012); p. 5635 – 5640;,
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