New downstream synthetic route of Ethyl 4-chloro-3-hydroxybutanoate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10488-69-4, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 10488-69-4, Ethyl 4-chloro-3-hydroxybutanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 10488-69-4, blongs to alcohols-buliding-blocks compound. Formula: C6H11ClO3

Preparation of (S) 6-chloro-5~hydroxy-N,N-diisopropyl-3-oxo hexanamide(Formula-12a) N-N-diisopropylacetamide (70 grams) added to a solution of 3500 ml of 1 molarLiHMDS solution, 650 ml of tetrahydrofuran at -50 to -700C. Stirred the reaction mixture for 25 minutes at -70 to -750C. Added 185 gram of ethyl-4-chloro-3 -hydroxy butanoate at -73 to -75¡ãC. Stirred the reaction for 1 hour at -48 to -45¡ãC. Quenched the reaction mixture with chilled water followed by hydrochloric acid solution. Separated the organic and inorganic phases. Washed the organic layer with 10percent sodium bicarbonate solution. Dried the organic layer using sodium sulfate and distilled the solvent completely under reduced pressure. Purified the residue in petroleum ether to get the title compound of formula- 12. Yield: 240 grams

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10488-69-4, its application will become more common.

Reference:
Patent; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; SAHADEVA REDDY, Maramreddy; WO2008/44243; (2008); A2;,
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