Extracurricular laboratory: Synthetic route of 2-Aminopropane-1,3-diol

With the rapid development of chemical substances, we look forward to future research findings about 534-03-2.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C3H9NO2

To a solution of compound 1 (20.0 g) in H20 (100 mL) were added Na2C03 (78 g) and compound 2 (21.5 g). The reaction mixture was stirred at rt for 16 h. Compound 3 (15.0 g, yield 58%) was obtained after standard work up procedure as a white solid.

With the rapid development of chemical substances, we look forward to future research findings about 534-03-2.

Reference:
Patent; SYNBLIA THERAPEUTICS, INC.; XIE, Yinong; BABISS, Lee, E.; (89 pag.)WO2019/89422; (2019); A1;,
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