Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4541-14-4, name is 4-(Benzyloxy)butan-1-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C11H16O2
To stirred solution of alcohol 21 (10 g, 55.5 mmol) in dichloromethane (150 mL) at 0 C were added pyridinium chlorochromate (17.96 g, 83.33 mmol) and Celite (17.96 g) and stirred at room temperature for 5 h. Diethyl ether (100 mL) was added and the reaction mixture was filtered through a small pad of Celite and silica gel. The filtered cake was washed thoroughly with ether (2 ¡Á 150 mL) and the filtrate was concentrated under reduced pressure. After flash column chromatography on silica gel (100-200 mesh, eluent: 8% EtOAc in hexane) aldehyde 22 (9.09 g, 92%) was obtained as a colorless liquid. 1H NMR (400 MHz, CDCl3): delta 9.76 (t, J = 1.5 Hz, 1H), 7.36-7.17 (m, 5H), 4.46 (s, 2H), 3.47 (q, J = 5.1 Hz, 2H), 2.53 (td, J = 7.0, 1.5 Hz, 2H), 1.92 (ddd, J = 13.0, 7.0, 6.0 Hz, 2H); 13C NMR (75 MHz, CDCl3): delta 201.3, 138.2, 128.4, 127.6, 73.0, 69.0, 41.0, 22.6; MASS (EIMS): m/z 178 (M)+.
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Reference:
Article; Venkatesham, Akkaladevi; Nagaiah, Kommu; Tetrahedron Asymmetry; vol. 23; 15-16; (2012); p. 1186 – 1197,12;,
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