Related Products of 124-68-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 124-68-5, name is 2-Amino-2-methyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows.
A 2 L Morton flask equipped with overhead stirring was charged with dichloromethane (200 ml_), 2-amino-2-methylpropan-1-ol (10.71 ml_, 112 mmol) and a saturated solution of sodium bicarbonate (200 ml_) and the reaction mixture was stirred. Benzyl chloroformate (16.61 ml_, 1 18 mmol) was added rapidly via syringe to the reaction mixture and stirring was continued (1H NMR after 6 hours indicated complete conversion). The mixture was poured into a separatory funnel and the layers were separated. The organic layer was washed with water and saturated sodium chloride, dried over sodium sulfate, and concentrated in vacuo to afford a colorless liquid (23.5 g). This liquid was purified by silica gel chromatography, eluting with ethyl acetate: heptane (1 :9 to 1 :1) to afford benzyl (1-hydroxy-2-methylpropan-2-yl)carbamate (13.61 g, 61.0 mmol, 54.3 % yield) as a colorless syrup. NMR (400 MHz, CD3SOCD3) d 1 .16 (s, 6 H), 3.35 (d, J = 6 Hz, 2 H), 4.69 (t, J = 6 Hz, 1 H), 4.97 (s, 2 H), 6.69 (br s, 1 H), 7.26-7.42 (m, 5 H); LC-MS (LC-ES) M+H = 224.
According to the analysis of related databases, 124-68-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CADILLA, Rodolfo; DEATON, David Norman; LARKIN, Andrew L; SCHULTE, Christie; SMALLEY JR, Terrence L.; (237 pag.)WO2020/95215; (2020); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts