Adding a certain compound to certain chemical reactions, such as: 111-41-1, N-(2-Hydroxyethyl)ethylenediamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 111-41-1, blongs to alcohols-buliding-blocks compound. Recommanded Product: N-(2-Hydroxyethyl)ethylenediamine
1), synthesis:To a 500 ml three-necked flask was added 104 g of hydroxyethyl ethylenediamine (1.0 mol), 94.7 g of paraformaldehyde (3 mol, 95%), stirred for 30 minutes, and at room temperature of 80-90 C 156.8 g of formic acid (3 mol, ), About 1 hour dropping end, continue to control the temperature of 80-90 C for 1 hour. 70g (vacuum-0.094MPa, kettle temperature: 80C) was distilled off under reduced pressure. The product was analyzed by gas chromatography at a concentration of 91.8% and 8% of the impurity S-2 (i.e., by-product N, N, N’-trimethyl-N’-ethylidene-ethylenediamine).2), transesterification:100 g of n-butanol was added to the three-necked flask of step 1) and the temperature was raised to 120 C for 4 hours to effect the reaction of the by-product N, N, N’-trimethyl-N’-ethylidene- Ammonia transesterification reaction to produce TMAEEA, by gas chromatography analysis, impurity S-2 content of 0.05%, after cooling back.3), distillation purification:The liquid of step 2) was transferred to a 500 ml rectification flask under reduced pressure at a vacuum of -0.094 MPa, a component at 62 C was n-butanol and a transesterified n-butanolate, 118 C component Ie product TMAEEA. A mixture of 139 g at 118 C was collected, the yield was 95.2% and the content was 99.9%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-41-1, its application will become more common.
Reference:
Patent; Sichuan Zhijiang High-tech Materials Co., Ltd.; Zhang Qi; Zhang Chao; Zhang Hua; Ye Xiaoming; Chen Xinzhi; (7 pag.)CN106748826; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts