Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate. A new synthetic method of this compound is introduced below., name: Ethyl 2-(hydroxymethyl)acrylate
General procedure: To a solution of the appropriate allylic alcohol 6 (1.00 equiv.) in dichloromethane (0.1 M) was added vinyl acetic acid 7 (1.20 equiv.), dicyclohexylcarbodiimide (1.20 equiv.) and 4-N,N-dimethylaminopyridine (0.15 equiv.) at 0C. The mixture was allowed to warm to ambient temperature and stirred until the product was fully converted (TLC). The solution was filtered and the filter cake was washed three times with dichloromethane. The combined organic layers were washed with aq. HCl (1 M) and then with saturated aq. NaHCO3 solution, dried with Na2SO4, filtered and dry-loaded on silica gel. The pure product was obtained after column chromatography on silica, using hexane/MTBE mixtures of increasing polarity as eluents.
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Reference:
Article; Schmidt, Bernd; Audoersch, Stephan; Kunz, Oliver; Synthesis; vol. 48; 24; (2016); p. 4509 – 4518;,
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