Reference of 1562-00-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1562-00-1, name is Sodium isethionate. This compound has unique chemical properties. The synthetic route is as follows.
0.675 mol of isethionic acid sodium salt (100.0 g) and 2.02 mol benzylchloride (233 mL) were mixed in a 750 mL multi-necked flask with KPG-stirrer. The mixture was heated at 70C inside temperature (95C outside temperature) and thenTriethylamine (120 mL) was added drop wise over one hour and the outside temperature was increased to 125C and maintained. Subsequently, outside temperature increased to 140C, and the inside temperature rose to 130C. A solid clustered at the stirrer, but went back into suspension. Hydrochloric acid vapors evolved.30 mL of triethylamine was added drop wise and then reacted for 1 .5 more hours. A viscous yellowish suspension formed. The product was allowed to cool to 50C inside temperature, then 300 mL water was added and vigorously stirred for 20 minutes and the mixture was transferred to a 2L separatory funnel. Then, the flask was rinsed out with 100 mL of water.The combined aqueous phases were washed twice with 280 mL dichloromethane.The aqueous phase was held at 40C, while KCI was added to the solution until saturated (about 130 g KCI). The mixture was filtered through a fluted filter and stored overnight in a refrigerator.The remaining solid was extracted and dried, resulting in 30.85 g, yield of 17.9%. fl: OH band is present, similar to the precursor.The mother liquor was again treated with KCI and stored (at 35-40C) overnight in the refrigerator.Solid from the second precipitation with KCI was filtered off and dried, resulting in 60.0 g = 34.9 % and the fl corresponds to the desired product.Solid 1: Was boiled with 150 mL EtCH and filtered while hot.By repeated precipitating with KCI, boiling and crystallization, 32 g of the product were obtained for a yield of 19 %.
According to the analysis of related databases, 1562-00-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GEISTLICH PHARMA AG; PFIRRMANN, Rolf W.; (101 pag.)WO2016/98054; (2016); A1;,
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