Electric Literature of 10213-78-2 ,Some common heterocyclic compound, 10213-78-2, molecular formula is C22H47NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In a 250 ml Erlenmeyer flask, 13 g (36 mmol) of N-octadecylamine in 100 ml of chloroform was dissolved and cooled to 0 C. Then, 7.95 ml (0.109 mol) of thionyl chloride was added dropwise to the cooled material. After completion of the addition, the reaction mixture was heated under chloroform reflux for 3 hours. An excess of the solvent and thionyl chloride were evaporated, and the residue taken up in dichloromethane was washed with Na2CO3 saturated solution, and washed several times with water until neutralization. The organic phase was dried over MgSO4, filtered, and concentrated under vacuum. The residue was purified by chromatography on a silica gel column using an ether/petroleum ether mixture (5:95 v/v) as eluent. This yielded 10 g of pure amine chloride as oil. Yield: 70%. Rf: 0.43 (ether/petroleum ether, 5:95 v/v). 1H NMR (200 MHz, CDCl3, HMDS) delta ppm: 3.38 (t, 4H, J=5.43 Hz, CH2-Cl), 2.75 (t, 4H, J=7.30 Hz, N-CH2-C-Cl), 2.43 (t, 2H, J=6.67 Hz, CH2-N), 1.36 (m, 2H, CH2-C-N), 1.16 (s1, 30H, CH2), 0.80 (t, 3H, J=5.85 Hz, CH3).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10213-78-2, its application will become more common.
Reference:
Patent; Yang Ji Chemical Company Ltd.; US2005/75345; (2005); A1;,
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