Electric Literature of 4654-39-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Potassium acetate (4.88 g, 49.7 mmol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(l,3,2-dioxaborolane) (7.6 g, 30 mmol) and PdCl2(dppf) (0.91 g, 1.2 mmol) were added to a solution of 2-(4-bromophenyl)ethanol (5.0 g, 25 mmol) in 1,4-dioxane (100 mL) under N2. The mixture was purged with N2 then stirred under N2 at about 85 C for about 12 h. After cooling to rt, water (100 mL) was added and the mixture was extracted with EtOAc (2 chi 100 mL). The combined organic layers were washed with saturated aqueous NaCl (100 mL) and dried over Na2SOzi, filtered and concentrated under reduced pressure. The residue was purified via flash chromatography on silica gel (17% EtO Ac/petroleum ether). The appropriate fractions were collected and concentrated under reduced pressure to give the title compound (6.2 g, 100%). NMR (400MHz, CDC13) delta 7.78 (d, J= 7.9 Hz, 2H), 7.29 – 7.23 (m, 2H), 3.87 (t, J= 6.6 Hz, 2H), 2.90 (t, J= 6.6 Hz, 2H), 1.36 (s, 12H).
According to the analysis of related databases, 4654-39-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBVIE INC.; BREINLINGER, Eric, C.; COX, Phil, B.; DAANEN, Jerome; DIETRICH, Justin; DJURIC, Stevan; DOMBROWSKI, Amanda, W.; FRANK, Kristine, E.; FRIEDMAN, Michael, M.; GOMTSYAN, Arthur; LI, Huan-Qui; LONGENECKER, Kenton; OSUMA, Augustine; ROWLEY, Ann, Marie; SCHMIDT, Robert; VASUDEVAN, Anil; WILSON, Noel; (378 pag.)WO2016/168641; (2016); A1;,
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