Application of 100442-33-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100442-33-9, name is 1-(3,3-Diphenyl-N-methylpropylamino)-2-methyl-2-propanol, molecular formula is C20H27NO, molecular weight is 297.4345, as common compound, the synthetic route is as follows.
2,N-Dimethyl-N-(3,3-diphenylpropyl)-l-amino-2-propanol (5g) and methyl acetoactate (7.5g) were dissolved in xylene (50 ml) at 25-30C followed by the addition of zinc dust (1.75g). The reaction mixture was heated at 140-145C for 7 hours. Next,25 xylene was distilled out along with simultaneous addition of xylene in order to maintain the volume of xylene in the reaction mixture. The reaction mixture was cooled at 25- 30C followed by filtration to remove the catalyst. Distillation was carried out to remove xylene under reduced pressure. The resulting residue was degassed for 1 hour to produce title compound as viscous brown oil.
Statistics shows that 100442-33-9 is playing an increasingly important role. we look forward to future research findings about 1-(3,3-Diphenyl-N-methylpropylamino)-2-methyl-2-propanol.
Reference:
Patent; ACTAVIS GROUP PTC EHF; WO2008/107797; (2008); A2;,
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